PMID: 9447862Feb 3, 1998Paper

31Phosphorus magnetic resonance spectroscopy characterization of muscular metabolic anomalies in patients with malignant hyperthermia: application to diagnosis

Anesthesiology
D BendahanP J Cozzone

Abstract

Metabolic anomalies are known in skeletal muscles of patients with malignant hyperthermia (MH). The authors used 31-phosphorus (31P) magnetic resonance spectroscopy (MRS) to compare metabolic changes of the finger flexor muscles recorded throughout two rest-exercise-recovery protocols (each including aerobic or ischemic exercise) in 26 healthy persons and in 13 MH-susceptible (MHS) persons who were unequivocally diagnosed by in vitro halothane-caffeine contracture tests on muscle biopsies. No abnormality was observed at rest and during recovery periods. A larger phosphocreatine decrease associated with an early drop of pH was noted during the first minute of both exercise periods for MHS patients compared with controls. The early pH decrease indicated a disorder affecting glycolytic activation, probably reflecting defects of Ca2+ cycling, and provided a sensitivity of 77% for MHS diagnosis. A diagnostic strategy based on the retrospective analysis of 19 selected MR parameters was developed. An MRS score, corresponding to the number of abnormal values among the 19 parameters, was calculated and provided sensitivity and specificity rates of 100%; that is, no false-positive or false-negative results were found. A prospective analy...Continue Reading

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Citations

Jan 20, 2000·Muscle & Nerve·E M BalogE M Gallant
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Sandrine GuisFrédéric Lioté
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch
Jan 31, 2007·British Journal of Sports Medicine·P M Hopkins
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Eran HadadYoram Epstein
Oct 3, 2006·Current Opinion in Anaesthesiology·P J Adnet, G A Gronert
Dec 26, 2001·Anesthesiology·Henry RosenbergSheila Muldoon
Jan 24, 2004·Anesthesiology·Thomas E NelsonSheila M Muldoon
Mar 1, 2008·Current Sports Medicine Reports·Sheila MuldoonRolf Bunger
Dec 16, 1998·Current Opinion in Neurology·K Hogan
Feb 3, 2009·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·John F HernandezS Jack McClarty
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Oct 11, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Sandrine GuisDavid Bendahan
May 25, 2002·Journal of the Royal Army Medical Corps·R J Booker, M C M Bricknell
Sep 6, 2000·Arquivos de neuro-psiquiatria·H C SilvaA M Tsanaclis
Sep 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·David AzriaEmmanuel Belamie

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