3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver

Biological & Pharmaceutical Bulletin
Yoshihisa KatoMasakuni Degawa

Abstract

A single intraperitoneal injection (50 mg/kg) of 3,3',4,4'-tetrachlorobiphenyl (CB77), a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-type polychlorinated biphenyl, led to significant decreases in the levels of serum total thyroxine (T4) and free T4 without increase in the level of serum thyroid-stimulating hormone at 7 d later in both TCDD-sensitive C57BL/6 and TCDD-resistant DBA/2 mice. When [(125)I]T4 was injected into the mice 7 d after treatment with CB77, the levels of biliary [(125)I]T4 and [(125)I]T4-glucuronide increased 90 to 120 min post injection in C57BL/6 mice, but not in DBA/2 mice, compared with levels in the corresponding control mice. In contrast, in both strains of mice, the CB77-pretreatment led to similar changes in the levels of the [(125)I]T4 bound to the serum transthyretin, albumin, and thyroxine-binding globulin. Consequently, treatment with CB77 promoted the clearance of [(125)I]T4 from the serum and further raised the steady-state volumes of distribution of [(125)I]T4, the concentration ratio (Kp value) of the liver to the serum, and the distribution of [(125)I]T4 in the liver in both strains of mice. The present findings indicate that in mice, the CB77-mediated decrease in the serum T4 level occurs th...Continue Reading

References

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Feb 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lloyd LecureuxLois D Lehman-McKeeman
Dec 31, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yoshihisa KatoMasakuni Degawa
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Oct 12, 2010·Toxicology and Applied Pharmacology·Yoshihisa KatoMasakuni Degawa
May 17, 2011·Toxicology and Applied Pharmacology·Yoshihisa KatoMasakuni Degawa
Jul 24, 2013·Biological & Pharmaceutical Bulletin·Yoshihisa KatoMasakuni Degawa

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