3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice.

Cells
Vijayasree V GiridharanRajarajan A Thandavarayan

Abstract

Aging is a predominant risk factor for the development and progression of cardiovascular complications. Physiologically and anatomically, the heart undergoes numerous changes that result in poor cardiac function in the elderly population. Recently, several studies have provided promising results, confirming the ability of the senescence-accelerated mouse-prone 8 (SAMP8) model to accurately model age-related cardiovascular alterations. In this study, using a murine model of senescence, SAMP8, we aimed to investigate the effect of 3,4-dihydroxybenzalacetone (DBL), a catechol-containing phenylpropanoid derivative isolated from Inonotus obliquus (Chaga), on cardiac aging. DBL was administered at the doses of 10 mg/kg and 20 mg/kg by oral gavage to SAMP8 mice to examine aging-mediated cardiac changes, such as oxidative DNA damage, oxygen radical antioxidant capacity (ORAC) value, fibrosis, inflammation, and apoptosis. The treatment with DBL at both doses significantly reduced aging-mediated oxidative DNA damage, and simultaneously increased the ORAC value in the SAMP8 assay. Cardiac fibrosis was assessed with Azan-Mallory staining, and the number of cardiac remodeling markers was found to be significantly reduced after the treatment...Continue Reading

References

May 3, 2003·Trends in Molecular Medicine·Peter M Kang, Seigo Izumo
Aug 2, 2007·Chemical & Pharmaceutical Bulletin·Yuki NakajimaTetsuya Konishi
Aug 14, 2010·Free Radical Biology & Medicine·Rajarajan A ThandavarayanYoshifusa Aizawa
Dec 15, 2010·Journal of Cardiovascular Pharmacology·Sanne de JongJacques M T de Bakker
Jun 15, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Katherine FormanJ A F Tresguerres
Jul 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Alana L ReedRoy L Sutliff
Sep 5, 2013·International Journal of Molecular Sciences·Krishnan VenkataramanT C Tai
Nov 28, 2013·Journal of Exercise Rehabilitation·Hyo-Bum Kwak
Aug 21, 2014·Aging·Jorge Pinto SoaresMaria Paula Mota
Jul 30, 2015·The Journal of Antibiotics·Byung Soon HwangBong-Sik Yun
Mar 19, 2016·Circulation Research·Joshua G TraversBurns C Blaxall
May 14, 2016·Circulation Research·Akihiro ShirakabeJunichi Sadoshima
Nov 9, 2016·Ageing Research Reviews·Vengadeshprabhu KaruppagounderRajarajan A Thandavarayan
Mar 17, 2017·GeroScience·Cesar A MeschiariMerry L Lindsey
Jul 29, 2018·Nature Reviews. Cardiology·Natalie A GudeMark A Sussman
Sep 7, 2018·Nature·Linda PartridgeP Eline Slagboom
Nov 9, 2018·Frontiers in Pharmacology·Bee Ling TanHeshu Sulaiman Rahman
Nov 16, 2018·Physiological Research·M KuchařováA Patková
May 1, 2019·Journal of Cardiovascular Development and Disease·Jennifer L RodgersSiva K Panguluri
Sep 25, 2019·Drug Development and Industrial Pharmacy·Yogesh Chand YadavKalpana Swain

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Methods Mentioned

BETA
Electrophoresis
fluorescence microscopy
Assay

Software Mentioned

CASP

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis