3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors

Bioorganic & Medicinal Chemistry Letters
Duncan ShawTimothy Harrison

Abstract

The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent gamma-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain A beta in transgenic mouse models and thus have potential as possible treatments for Alzheimer's disease.

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Nov 9, 2005·Bioorganic & Medicinal Chemistry Letters·Ian ChurcherJonathan D J Wrigley

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Citations

Feb 20, 2021·ACS Medicinal Chemistry Letters·Jaden Jungho JunSanjay V Malhotra
Jul 23, 2021·ACS Chemical Neuroscience·Ángel SantiagoLaura Dominguez
Dec 1, 2020·Journal of the American Chemical Society·Kai LangX Peter Zhang

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