PMID: 11351932May 16, 2001Paper

3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose

Psychopharmacology
B EstebanM I Colado

Abstract

There is good evidence that 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity results from free radical formation. However, it is unclear whether it is the presence of MDMA or a metabolite in the brain that initiates this process. We wished to measure the concentration of MDMA in the brain following peripheral administration of neurotoxic doses and examine the effect on acute monoamine release and the subsequent neurotoxic loss in 5-hydroxytryptamine (5-HT) content when a high concentration of MDMA was infused into cerebral tissue. Selectively placed microdialysis probes were used to determine both the concentration of MDMA in the brain following peripheral injection and the degree of 5-HT release. Monoamines in dialysate and tissue were measured with standard HPLC techniques. MDMA, administered intraperitoneally, at doses of 10 and 15 mg/kg, which produce neurodegeneration, resulted in an estimated cerebral extracellular concentration of MDMA of 11 and 20 microM, respectively. When MDMA (100-400 microM) was perfused through a selectively placed microdialysis probe it dose-dependently increased 5-HT release in the hippocampus and dopamine release in the striatum. Seven days after perfusion of MDMA the concentration...Continue Reading

Citations

Jan 22, 2004·Psychopharmacology·Elizabeth Anne JohnsonDiane B Miller
Jan 14, 2009·Psychopharmacology·A R GreenKevin C F Fone
Feb 3, 2009·Analytical and Bioanalytical Chemistry·Melanie MuellerHans H Maurer
Sep 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Ralph BuchertMalte Clausen
Apr 18, 2009·Molecular Neurobiology·J P CapelaFélix Carvalho
Apr 10, 2004·Drug and Alcohol Dependence·Sotiria BexisRodney J Irvine
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·J C Cole, H R Sumnall
Aug 7, 2002·Pharmacology & Therapeutics·Richard B Rothman, Michael H Baumann
Apr 2, 2003·Pharmacology & Therapeutics·J C Cole, H R Sumnall
May 12, 2011·Chemical Research in Toxicology·Anne NeudörfferMartine Largeron
Nov 29, 2001·British Journal of Pharmacology·D M CannonG J McBean
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Esther O'SheaM I Colado
Mar 24, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-Christophe CasselRolf Jackisch
Dec 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Annmarie Ramkissoon, Peter G Wells
Jul 25, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Melanie MuellerG A Ricaurte
Oct 19, 2007·PLoS Biology·Jason M WilliamsAurelio Galli
Dec 29, 2012·PloS One·Stanley C FlavelGabrielle Todd
Nov 2, 2013·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
Dec 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M HerndonTerrence J Monks
Mar 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M HerndonTerrence J Monks
Mar 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel José BarbosaFélix Carvalho
Mar 2, 2016·Forensic Science International : Synergy·Merete VevelstadMarianne Arnestad
Feb 6, 2003·Rapid Communications in Mass Spectrometry : RCM·Nieves PizarroRafael de la Torre
Dec 1, 2012·Toxicology Letters·Patrícia Silva FerreiraJ P Capela
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Susan Schenk
Oct 19, 2010·European Journal of Pharmacology·Natacha Vanattou-SaïfoudineNeuropsychopharmacology Research Group
Nov 24, 2007·Pharmacology, Biochemistry, and Behavior·G A Gudelsky, B K Yamamoto

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