3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jae-Won LeeWanjoo Chun

Abstract

Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as neuronal protection against excitotoxicity and anti-inflammatory property, the biological activity of 3,4,5-trihydroxycinnamic acid (THC), a derivative of hydroxycinnamic acids, has not been clearly examined. The objective of the present study is to evaluate the anti-inflammatory effects of THC on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. THC significantly suppressed LPS-induced excessive production of nitric oxide (NO) and expression of iNOS, which is responsible for the production of iNOS. THC also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1β and TNF-α in BV2 microgilal cells. Furthermore, THC significantly suppressed LPS-induced degradation of IκB, which retains NF-κB in the cytoplasm. Therefore, THC attenuated nuclear translocation of NF-κB, a major pro-inflammatory transcription factor. Taken together, the present study for the first time demonstrates that THC exhibits anti-inflammatory activity through the suppression of NF-κB transcriptional activation in LPS-stimulated BV2 microglial cells.

References

Oct 1, 1992·The Journal of Infectious Diseases·C C ChaoP K Peterson
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Oct 1, 1989·Journal of Neuroimmunology·S ItagakiD Selkoe
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Aug 1, 1996·Trends in Neurosciences·J E Merrill, E N Benveniste
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
May 15, 2007·Biochemical and Biophysical Research Communications·Reiko NagasakaHideki Ushio
Jun 16, 2007·International Immunopharmacology·Dong-Oh MoonGi-Young Kim
Feb 19, 2008·International Immunopharmacology·Long Tai ZhengKyoungho Suk
Dec 17, 2008·Current Pharmaceutical Design·Antonino TuttolomondoGiuseppe Licata
May 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiyeon OckKyoungho Suk
Dec 17, 2009·Acta Neuropathologica·Manuel B Graeber, Wolfgang J Streit
Nov 6, 2010·Archives of Pharmacal Research·Young Choong Kim
Apr 5, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jae-Won LeeWanjoo Chun

❮ Previous
Next ❯

Citations

Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Eun-Jin YangChang-Gu Hyun
Jul 17, 2016·BMC Complementary and Alternative Medicine·Seong Eun JinSoo-Jin Jeong
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Van Anh VoWanjoo Chun
Oct 30, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jinyoung HurYoung-Wuk Cho
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qian LiuXuebo Liu
Dec 31, 2019·Chembiochem : a European Journal of Chemical Biology·Somchart MaenpuenThanyaporn Wongnate
Mar 23, 2021·European Journal of Pharmacology·Mengting ZhouYunxia Li

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
confocal microscopy
nuclear translocation
nuclear transclocation

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.