3,4,5-Triiodobenzoic acid affects [3H]verapamil binding to plant and animal membrane fractions and smooth muscle contraction

Biochemical and Biophysical Research Communications
E AndrejauskasD Marmé

Abstract

3,4,5-Triiodobenzoic acid, known as auxin transport inhibitor, stimulates specific [3H]verapamil binding to zucchini microsomes by 100% (EC50 = 1 microM). This stimulatory effect is due to a decrease of the apparent equilibrium dissociation constant KD for verapamil from 60 nM to 33 nM without significantly changing the maximum number of binding sites. 3,4,5-Triiodobenzoic acid also increases specific [3H]verapamil binding to rabbit skeletal muscle membranes (EC50 greater than or equal to 20 microM) without affecting [3H]nitrendipine and [3H]-d-cis-diltiazem binding. If 3,4,5-triiodobenzoic acid is added to isolated rings of rabbit A. saphena contracted by potassium depolarization, a dose-dependent relaxation is observed with an IC50 value of about 8 microM. Contractions initiated by the addition of 3 microM norepinephrine can also be abolished by 3,4,5-triiodobenzoic acid with half maximal inhibition at 40 microM.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Jan 1, 1984·Journal of Cardiovascular Pharmacology·C CauvinC van Breemen
Oct 12, 1983·Biochimica Et Biophysica Acta·T J BeelerJ M Keffer
Nov 8, 1982·FEBS Letters·D R Ferry, H Glossmann
Aug 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·H Glossmann, D R Ferry
Jan 13, 1984·Biochemical and Biophysical Research Communications·J P GalizziM Lazdunski
May 1, 1973·Plant Physiology·R K Dela Fuente, A C Leopold
Oct 1, 1984·Plant Physiology·R K Dela Fuente
Oct 1, 1984·Plant Physiology·C C de Guzman, R K Dela Fuente

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