3,5-Di-O-caffeoyl-epi-quinic acid from the leaves and stems of Erigeron annuus inhibits protein glycation, aldose reductase, and cataractogenesis

Biological & Pharmaceutical Bulletin
Dae Sik JangJin Sook Kim

Abstract

In our ongoing project directed toward the discovery of novel treatments for diabetic complications from herbal medicines, sixteen compounds including three caffeoylquinic acids and four flavonoids were isolated from an EtOAc-soluble extract of the stems and leaves of Erigeron annuus. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR). Of these, 3,5-di-O-caffeoyl-epi-quinic acid (3) exhibited the most potent inhibitory activity in both the AGEs and aldose reductase (AR) assays. Compound 3 markedly reduced AGEs-bovin serum albumin (BSA) cross-linking in a dose-dependent manner. Furthermore, opacity of lenses was significantly prevented when they were treated with 3 in an ex vivo experiment.

References

Jan 1, 1984·Diabetes·R L Engerman, T S Kern
Aug 1, 1994·Trends in Pharmacological Sciences·D R TomlinsonL T Diemel
Feb 24, 2001·Diabetologia·J M ForbesM E Cooper
Aug 10, 2002·Phytochemistry·Hyuncheol OhTae-Oh Kwon
Jul 23, 2003·Current Medicinal Chemistry·K KawanishiM Moriyasu
Dec 4, 2003·Bioorganic & Medicinal Chemistry·Hisashi MatsudaMasayuki Yoshikawa
Dec 20, 2003·American Journal of Nephrology·W Kline BoltonUNKNOWN ACTION I Investigator Group
Nov 26, 2004·Journal of Agricultural and Food Chemistry·Xianfeng ZhuRaymond Lo
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
Mar 17, 2005·Planta medica·Xin LiKun Gao
May 21, 2005·Journal of Ethnopharmacology·Young-Shin ChungEun-Kyung Hong
May 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaoyan ChenDafang Zhong
May 25, 2006·Current Medicinal Chemistry·Mankil JungSang Ki Kim
Jun 24, 2006·Drug Discovery Today·V Prakash Reddy, Ayse Beyaz
Jun 30, 2006·Phytochemistry·Sithes LogendraIlya Raskin
Jul 28, 2006·Carbohydrate Research·M Iqbal Choudhary Atta-ur-Rahman
Sep 19, 2006·Pathologie-biologie·J Peyroux, M Sternberg
Dec 14, 2006·Plant & Cell Physiology·Ji Hoon AhnJong Seob Lee
May 11, 2007·Archives of Pharmacal Research·Xiang Hua HanBang Yeon Hwang
Oct 24, 2007·Journal of Lipid Research·Myoung Sook HanMyung-Shik Lee
Nov 6, 2007·Biological & Pharmaceutical Bulletin·Dae Sik JangJin Sook Kim
Mar 5, 2008·The Review of Scientific Instruments·S J YooM P Hong
May 2, 2008·Pharmacotherapy·Mary Ann Ramirez, Nancy L Borja
May 14, 2008·Current Pharmaceutical Design·Masayoshi Takeuchi, Sho-ichi Yamagishi
Apr 1, 1998·American Journal of Botany·C Bennington, D Stratton

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Citations

Apr 22, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izabela Sadowska-BartoszGrzegorz Bartosz
Feb 27, 2013·Free Radical Research·R Thiagarajan, R Manikandan
Sep 5, 2013·Colloids and Surfaces. B, Biointerfaces·Pavan SunkireddySubhash C Yadav
Nov 26, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyun Ah JungJae Sue Choi
Apr 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nasrin ZiamajidiAfshin Abdirad
Aug 12, 2014·Critical Reviews in Food Science and Nutrition·Jianbo XiaoXiaoqing Chen
Sep 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung Hwan HwangSoon Sung Lim
Mar 25, 2017·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Amandeep KaurParveen Bansal
Feb 19, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izabela Sadowska-Bartosz, Grzegorz Bartosz
Sep 12, 2019·Archives of Physiology and Biochemistry·Abdulrahman L Al-Malki
Jul 3, 2019·Frontiers in Pharmacology·Devesh TewariGianina Crişan
Sep 16, 2017·Acta Biochimica Et Biophysica Sinica·Nuramina MamatAisa Haji Akber
Jan 28, 2017·Phytotherapy Research : PTR·Ivana MiláčkováJan Hošek
Oct 27, 2018·Journal of Pesticide Science·Said Salama MoselhyIman M Ismail
Oct 4, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Sheldon RowanAllen Taylor

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