PMID: 7033290Dec 1, 1981Paper

3,5-Dimethyl-3'-isopropyl-l-thyronine therapy in diabetic pregnancy: stimulation of rabbit fetal lung phospholipids

The Journal of Clinical Investigation
N D Neufeld, S Melmed

Abstract

Diabetes mellitus in pregnancy is associated with neonatal respiratory distress syndrome due to impaired synthesis of fetal lung surfactant. Pharmacologic agents that promote fetal lung maturity are diabetogenic and have limited use in the management of diabetic pregnancy for prevention of respiratory distress syndrome. Maternal administration of a thyroid analog 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) results in significant enhancement of fetal lung phospholipid synthesis and accelerated lung maturity. We therefore studied the effects of DIMIT (0.5 mg/kg per d, s.c.) administration to pregnant alloxan-diabetic rabbits on days 25 and 26 of gestation. DIMIT treatment of diabetic maternal rabbits (DD) was associated with reduction of maternal blood glucose (115 +/- 13 vs. 275 +/- 72 mg/dl, P less than 0.05) and fetal glucose (64 +/- 6 vs. 274 +/- 47 mg/dl, P less than 0.001) compared with saline-injected diabetic (D) mothers. Reduction of fetal insulin levels was also associated with maternal DIMIT therapy in diabetic rabbits (56 +/- 5 (D) vs. 24 +/- 4 microunits/ml, P less than 0.001). Maternal diabetes resulted in significant reduction of fetal lung weight (370 +/- 20 vs. 520 +/- 30 mg, P less than 0.005) and lung protein...Continue Reading

References

Mar 1, 1978·British Journal of Obstetrics and Gynaecology·C BorbergN W Oakley
Dec 1, 1979·Lancet·W SchönbergerW Gempp
Jan 1, 1979·Journal of Perinatal Medicine·S MashiachD M Serr
Jun 1, 1979·Pediatric Research·N D NeufeldS A Kaplan
Dec 1, 1979·Pediatric Research·A SevanianC T Barrett
Jun 1, 1978·Endocrinology·F ComiteE C Jorgensen
Aug 5, 1976·The New England Journal of Medicine·R A CuestasR R Engel
Feb 12, 1976·The New England Journal of Medicine·M F RobertM E Avery
Oct 1, 1974·Pediatric Research·B T Smith, J S Torday
Sep 1, 1974·Pediatric Research·A ErenbergD A Fisher
Jan 1, 1973·Biology of the Neonate·B WuC D Cook
May 1, 1965·Analytical Biochemistry·E Van Handel
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·N D NeufeldB M Lippe
Jul 1, 1981·Pediatric Research·N D NeufeldS A Kaplan
Jun 1, 1980·The Journal of Clinical Investigation·P L BallardE C Jorgensen

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Citations

Sep 1, 1989·Metabolism: Clinical and Experimental·N D NeufeldN Tadokoro

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