PMID: 9188085May 12, 1997Paper

3.5% hypertonic saline produces sympathetic activation in hemorrhaged rabbits

Journal of the Autonomic Nervous System
K SekiS Ogura

Abstract

The neural mechanisms for pressor effects after hypertonic saline infusion are still unclear. Using direct measurement of the renal sympathetic nerve activity (RNA), we tested the hypothesis that the autonomic nervous system is involved in an acute blood pressure elevation produced by hypertonic saline (HTS) in anesthetized rabbits subjected to hemorrhage. Twenty urethane-anesthetized rabbits were ventilated mechanically after a tracheostomy and paralyzed with gallamine triethiodide. Heart rate (HR), mean blood pressure (MBP) and central venous pressure (CVP) were measured simultaneously with RNA. The animals were divided into the following four groups: (1) animals with intact baroreceptors that received HTS (intact HTS group, N = 5); (2) those with intact baroreceptors that received normal saline (intact NS group, N = 5); (3) those that underwent selective cervical vagotomy (vagotomy group, N = 5); (4) those with sino-aortic denervation (SAD group, N = 5). The last two groups were given HTS only. After inducing hemorrhagic hypotension to 40 mmHg over 10 min, 3.5% HTS at half the volume of shed blood was infused over approximately 120 s. In the intact HTS group, sympathetic activation, associated with tachycardia and pressor ef...Continue Reading

Citations

Feb 11, 2004·The Journal of Pharmacology and Experimental Therapeutics·Patrick Osei-Owusu, Karie E Scrogin
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M J KenneyR J Fels

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