3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

Virology
Reed F JohnsonWayne A Marasco

Abstract

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.

References

Oct 1, 1991·The American Review of Respiratory Disease·S G Von EssenS I Rennard
Sep 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anatoli GiritchYuri Gleba
Dec 11, 2007·Nature Biotechnology·Wayne A Marasco, Jianhua Sui
Aug 13, 2011·Expert Opinion on Biological Therapy·Kristin A Shadman, Ellen R Wald
Oct 9, 2012·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V M CormanC Drosten
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Apr 5, 2013·The New England Journal of Medicine·Vincent J MunsterHeinz Feldmann
Apr 6, 2013·Zoonoses and Public Health·A VincentJ Ciacci-Zanella
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitVincent J Munster
Nov 13, 2013·The Journal of Infectious Diseases·Yanfeng YaoChuan Qin
Feb 8, 2014·Human Vaccines & Immunotherapeutics·Xiangguo Qiu, Gary P Kobinger
Mar 1, 2014·Medical Image Computing and Computer-assisted Intervention : MICCAI·Ziyue XuDaniel J Mollura
Mar 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jincun ZhaoStanley Perlman
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xian-Chun TangWayne A Marasco
May 23, 2014·Immunologic Research·Rudragouda ChannappanavarStanley Perlman
Jul 16, 2014·IEEE Transactions on Medical Imaging·Awais MansoorDaniel J Mollura
Aug 22, 2014·PLoS Pathogens·Darryl FalzaranoVincent J Munster
Nov 25, 2014·Emerging Infectious Diseases·Danielle R AdneyVincent J Munster
Jan 16, 2015·Journal of Virology·Anurodh Shankar AgrawalChien-Te K Tseng
Jun 17, 2015·Emerging Infectious Diseases·Abdelmalik I KhalafallaDean D Erdman
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kristen E PascalChristos A Kyratsous
Jul 29, 2015·Nature Communications·Lingshu WangBarney S Graham

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Citations

May 19, 2016·Emerging Infectious Diseases·Timothy M UyekiArmen Donabedian
Sep 3, 2016·The Journal of Antimicrobial Chemotherapy·Yin Mo, Dale Fisher
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Dec 13, 2016·Expert Review of Anti-infective Therapy·Jaffar A Al-Tawfiq, Ziad A Memish
Sep 1, 2017·Journal of Medical Microbiology·Ali A RabaanHatem M Alhani
Nov 29, 2016·Nature Microbiology·Adam S CockrellRalph S Baric
Aug 18, 2016·Emerging Microbes & Infections·Jennifer LambourMireia Pelegrin
Oct 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huiwen ZhengLongding Liu
Mar 9, 2019·Expert Opinion on Drug Discovery·Allison L Totura, Sina Bavari
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Oct 17, 2019·International Journal of Molecular Sciences·Sang Il KimJunho Chung
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
Jul 14, 2020·Nature·Ann M ArvinHerbert W Virgin
Aug 31, 2016·Annual Review of Medicine·Anthony R FehrStanley Perlman
Aug 23, 2017·Expert Review of Respiratory Medicine·Ali A Rabaan
Jun 15, 2018·Médecine sciences : M/S·Garance CastinoAnaïs Vignon
Jul 26, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Adam S CockrellRalph S Baric
Jun 7, 2019·Emerging Microbes & Infections·Jiuyang XuLinqi Zhang
Mar 24, 2020·Future Virology·Hani ChoudhryMohammad Sarwar Jamal
May 12, 2020·Frontiers in Microbiology·Longping V TseRalph S Baric
May 15, 2020·AAPS PharmSciTech·Junqiang YanHua Fan
Oct 24, 2019·BMC Infectious Diseases·Abdulrahman Mohammed G HabibNazmus Saquib
May 2, 2020·Scientific Reports·Gael Darren MagangaEric Maurice Leroy
Jun 5, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nikoo Hossein-KhannazerMassoud Vosough
Oct 30, 2020·Pharmaceutics·Wanling LiangJenny K W Lam
Mar 18, 2021·Infectious Diseases of Poverty·Lan-Gui SongZhi-Yue Lv
Mar 18, 2021·ImmunoTargets and Therapy·Amal HasanFahd Al-Mulla
Apr 27, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Deepak KumarNagendra R Hegde
May 6, 2021·Archives of Virology·Sana ShabbirMuhammad Jawad Khan

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Methods Mentioned

BETA
transgenic
bronchoalveolar lavage
blood draws
light microscopy

Software Mentioned

Graphpad Prism

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