3D bioprinting for drug discovery and development in pharmaceutics

Acta Biomaterialia
Weijie PengIbrahim T Ozbolat

Abstract

Successful launch of a commercial drug requires significant investment of time and financial resources wherein late-stage failures become a reason for catastrophic failures in drug discovery. This calls for infusing constant innovations in technologies, which can give reliable prediction of efficacy, and more importantly, toxicology of the compound early in the drug discovery process before clinical trials. Though computational advances have resulted in more rationale in silico designing, in vitro experimental studies still require gaining industry confidence and improving in vitro-in vivo correlations. In this quest, due to their ability to mimic the spatial and chemical attributes of native tissues, three-dimensional (3D) tissue models have now proven to provide better results for drug screening compared to traditional two-dimensional (2D) models. However, in vitro fabrication of living tissues has remained a bottleneck in realizing the full potential of 3D models. Recent advances in bioprinting provide a valuable tool to fabricate biomimetic constructs, which can be applied in different stages of drug discovery research. This paper presents the first comprehensive review of bioprinting techniques applied for fabrication of 3...Continue Reading

References

Sep 11, 1999·Trends in Biotechnology·D J Odde, M J Renn
Mar 10, 2004·Journal of Biomolecular Screening·Huangpin Ben HsiehScott Elrod
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Sep 4, 2004·Environmental Health Perspectives·Guido SteinerStefan Ruepp
Jan 29, 2005·Drug Discovery Today·Phillip Gribbon, Andreas Sewing
May 3, 2005·Nature Reviews. Drug Discovery·Howard Rosen, Thierry Abribat
Sep 16, 2006·Journal of Biomolecular Screening·Andrea Ivascu, Manfred Kubbies
Jul 24, 2007·Nature Reviews. Drug Discovery·Jeffrey A KramerDale L Morris
Aug 21, 2007·Expert Opinion on Biological Therapy·Phil G Campbell, Lee E Weiss
Aug 24, 2007·Lab on a Chip·Utkan Demirci, Grace Montesano
Mar 26, 2008·BioTechniques·Karina BakuntsNarine Sarvazyan
May 13, 2008·Gastroenterology·Harmeet Malhi, Gregory J Gores
Jun 12, 2008·Tissue Engineering. Part C, Methods·Robert ChangWei Sun
Jun 19, 2008·Biochemical and Biophysical Research Communications·Jason W NicholLisa E Freed
Sep 2, 2008·Tissue Engineering. Part a·Tao XuJames J Yoo
Apr 17, 2009·Neuroreport·Wonhye LeeSeung-Schik Yoo
Jun 13, 2009·Current Opinion in Pharmacology·Xavier GidrolBéatrice Schaack
Jul 10, 2009·Tissue Engineering. Part C, Methods·SangJun MoonUtkan Demirci
Jul 16, 2009·Combinatorial Chemistry & High Throughput Screening·Eric D MillerLee E Weiss
Feb 20, 2010·Nature Reviews. Drug Discovery·Steven M PaulAaron L Schacht
May 8, 2010·Circulation Research·Arne HansenThomas Eschenhagen
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Jul 1, 2010·Biotechnology and Bioengineering·Xiaofeng CuiThomas Boland
Dec 3, 2010·Journal of Biomolecular Screening·Vy Lam, Tetsuro Wakatsuki
Dec 15, 2010·The American Journal of Cardiology·Briget da Graca, Giovanni Filardo
Jan 19, 2011·Advanced Drug Delivery Reviews·Florian GroeberKatja Schenke-Layland
May 19, 2011·Tissue Engineering. Part C, Methods·Martin GrueneBoris Chichkov
Jun 28, 2011·Nature Reviews. Drug Discovery·David C Swinney, Jason Anthony
Oct 29, 2011·Trends in Cell Biology·Dongeun HuhDonald E Ingber
Jan 19, 2012·Pharmacology & Therapeutics·Anna AstashkinaDavid W Grainger
Feb 14, 2012·Current Opinion in Biotechnology·Markus Rimann, Ursula Graf-Hausner

❮ Previous
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Citations

Nov 6, 2018·Expert Opinion on Drug Discovery·Aishwarya SatpathyIbrahim T Ozbolat
Jan 25, 2019·Expert Opinion on Drug Discovery·Sina Azizi MachekposhtiRoger J Narayan
Feb 16, 2019·Biofabrication·Alireza Shahin-Shamsabadi, P Ravi Selvaganapathy
Sep 7, 2019·Biomedical Materials·Erick K BreathwaiteJung Bok Lee
Mar 4, 2020·Advanced Healthcare Materials·Jing NieYong He
Dec 2, 2017·Advanced Healthcare Materials·Guifang GaoXiaofeng Cui
May 20, 2020·International Journal of Molecular Sciences·Brian E GrottkauYonggang Pang
Sep 27, 2020·International Journal of Molecular Sciences·Tullio GenovaFederico Mussano
Oct 3, 2018·Journal of Cellular Physiology·Francesca SensiMarco Agostini
Dec 2, 2017·Clinical and Experimental Pharmacology & Physiology·Miranda D Grounds
Mar 18, 2020·Science Advances·Bugra AyanIbrahim T Ozbolat
Jun 11, 2020·Nature Biotechnology·Fabio MotaBernardo Cabral
Aug 15, 2020·NPJ Precision Oncology·Pallab DattaIbrahim T Ozbolat
Sep 4, 2019·Expert Opinion on Drug Delivery·Sarah J TrenfieldAbdul W Basit
Nov 27, 2019·Biomicrofluidics·Jiahui SunXianting Ding
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Juliana R DiasAna L Oliveira
Nov 18, 2018·Journal of Cellular Physiology·Rahul MittalVasanti M Jhaveri
Jun 20, 2019·Nanoscale Research Letters·Camila Faccini de LimaAlexander Gumennik
Aug 6, 2020·Scientific Reports·Bugra AyanIbrahim T Ozbolat
Sep 28, 2018·SLAS Technology·Shiqing Zhang, Haibin Wang
Dec 14, 2018·Biofabrication·Ricardo da Conceicao RibeiroKenneth Dalgarno
Oct 8, 2020·Small·Flavia FontanaHélder A Santos
Jan 26, 2021·Translational Oncology·Robin AugustineAnwarul Hasan
Nov 1, 2020·Biomaterials·Wissam FarhatAlexandra Fuchs
Feb 12, 2021·Drug Discovery Today·Meghana Tushar Parikh
Mar 4, 2021·Pharmaceutics·Sandra Ruiz-AlonsoJosé Luis Pedraz
Mar 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Iria Seoane-ViañoAlvaro Goyanes
Mar 6, 2021·NPJ Precision Oncology·Pallab DattaIbrahim T Ozbolat
Mar 7, 2021·Gels·Xabier MoralesCarlos Ortiz-de-Solorzano
Jun 27, 2019·Biosensors & Bioelectronics·Niharika GuptaBansi D Malhotra
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Kazim K MoncalIbrahim T Ozbolat
Jun 18, 2018·Biotechnology Advances·Pallab DattaIbrahim T Ozbolat
Mar 7, 2021·International Journal of Pharmaceutics·Susannah Elizabeth EvansRonan Daly
Mar 21, 2021·Drug Discovery Today·Arpita P TiwariHelen Townley
Jul 9, 2020·Bioactive Materials·Mingze SunKazunori Hoshino

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