3D CMRO2 mapping in human brain with direct 17 O MRI: Comparison of conventional and proton-constrained reconstructions

NeuroImage
Dmitry KurzhunovMichael Bock

Abstract

Oxygen metabolism is altered in brain tumor regions and is quantified by the cerebral metabolic rate of oxygen consumption (CMRO2). Direct dynamic 17O MRI with inhalation of isotopically enriched 17O2 gas can be used to quantify CMRO2; however, pixel-wise CMRO2 quantification in human brain is challenging due to low natural abundance of 17O isotope and, thus, the low signal-to-noise ratio (SNR) of 17O MR images. To test the feasibility CMRO2 mapping at a clinical 3 T MRI system, a new iterative reconstruction was proposed, which uses the edge information contained in a co-registered 1H gradient image to construct a non-homogeneous anisotropic diffusion (AD) filter. AD-constrained reconstruction of 17O MR images was compared to conventional Kaiser-Bessel gridding without and with Hanning filtering, and to iterative reconstruction with a total variation (TV) constraint. For numerical brain phantom and in two in vivo data sets of one healthy volunteer, AD-constrained reconstruction provided 17O images with improved resolution of fine brain structures and resulted in higher SNR. CMRO2 values of 0.78 - 1.55µmol/gtissue/min (white brain matter) and 1.03 - 2.01µmol/gtissue/min (gray brain matter) as well as the CMRO2 maps are in a goo...Continue Reading

Citations

Nov 3, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitry KurzhunovMichael Bock
May 18, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitry KurzhunovMichael Bock
Jun 13, 2019·Topics in Magnetic Resonance Imaging : TMRI·Sebastian C NiesporekTanja Platt
May 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Ruomin HuLothar R Schad
Feb 20, 2020·Radiology·Otto Rapalino
Apr 3, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vilakshan AlambyanCiro Ramos-Estebanez
Oct 17, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sebastian C NiesporekArmin M Nagel
Oct 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karthik LakshmananRyan Brown
Apr 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderGiles Santyr

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