3D conformal HDR-brachy- and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: clinical experience with 3 year follow-up

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
R PötterTomas-Hendrik Knocke-Abulesz

Abstract

To assess feasibility, safety and effectiveness of CT-based 3D conformal external beam radiotherapy (EBRT) plus concurrent cisplatin and MRI-based 3D conformal HDR-brachytherapy (HDR-BT) in the treatment of advanced cervical cancer. A total of 48 patients with advanced cervical cancer, treated with CT-based EBRT plus simultaneous cisplatin chemotherapy (40mg/m(2) of body surface per week for 5 weeks) and MRI-based HDR-BT, were included for analysis. All patients completed radiotherapy as planned and 90% received at least four cycles chemotherapy. Frequencies of CTC grade 3 anaemia, grade 3-4 leucopenia and grade 3 thrombocytopenia were 4, 23 and 10%, respectively. Two patients developed deep vein thrombosis and one non-fatal pulmonary embolism. Grade 4 genitourinary late side effects (bladder) occurred in 2 patients. No grade 3-4 gastrointestinal side effects were observed. Complete response (CR) was obtained in 45 patients (94%). After a median follow-up of 33 months, 27 patients were disease free. Actuarial overall survival at 3 years was 61%, progression free survival 51% and continuous complete remission for true pelvis 85%. MRI-based 3D HDR-BT and 3D EBRT plus cisplatin appears to be safe and effective, although acute haem...Continue Reading

References

May 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A W FylesG A Rawlings
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·L SouhamiC R Freeman
Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·B G ClarkJ F Fowler
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R PearceyD Tu
Mar 15, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederUNKNOWN Gynaecological (GYN) GEC-ESTRO Working Group
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Christian KirisitsDietmar Georg

❮ Previous
Next ❯

Citations

May 15, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Johannes C A DimopoulosRichard Pötter
Feb 5, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Chi-Shing Cho
Feb 20, 2009·International Journal of Clinical Oncology·Takafumi Toita
Feb 9, 2012·Chemotherapy Research and Practice·Seiji Mabuchi, Tadashi Kimura
Apr 14, 2010·International Journal of Radiation Oncology, Biology, Physics·Petra GeorgRichard Pötter
May 29, 2009·International Journal of Radiation Oncology, Biology, Physics·Christopher J AnkerDavid K Gaffney
Feb 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Petra GeorgRichard Pötter
Dec 9, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes C A DimopoulosRichard Pötter
Sep 16, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Primoz PetricRichard Pötter
Jun 6, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·R PötterJ Dimopoulos
Jan 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Jacob C LindegaardJohn Gelineck
Jan 8, 2008·The Lancet Oncology·Lisa Barbera, Gillian Thomas
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sandy MohamedKari Tanderup
Aug 9, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard PötterChristian Kirisits
Feb 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Petra GeorgWolfgang Dörr
May 29, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mihai LevitchiDidier Peiffert
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio Carlos ZulianiLuis Otávio Sarian
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkWui-Jin Koh
Feb 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rafael Martínez-MongeMatías Jurado
Jul 17, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Radovan VojtíšekJindřich Fínek
Aug 23, 2011·Journal of Radiation Research·Yu OhkuboTakashi Nakano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
R PötterC Kirisits
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C Haie-MederGynaecological (GYN) GEC-ESTRO Working Group
© 2021 Meta ULC. All rights reserved