3D conformal intensity-modulated radiotherapy planning: interactive optimization by constrained matrix inversion

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C De WagterW J De Neve

Abstract

This paper presents a method for interactive optimization of 3D conformal intensity-modulated radiotherapy plans employing a quadratic objective that also contains dose limitations in the organs at risk. This objective function is minimized by constrained matrix inversion (CMI) that follows the same approach as the gradient technique using matrix notation. Sherouse's GRATIS radiotherapy design system is used to determine the outlines of the target volume and the organs at risk and to input beam segments which are given by the beam segmentation technique. This technique defines the beam incidences and the beam segmentation. The weights of the segments are then calculated using a quadratic objective function and CMI. The objective function to be minimized consists of two components based on the planning target volume (PTV) and the organ at risk (OAR) with an importance factor w associated with the OAR. Optimization is tested for concave targets in the head and neck region wrapping around the spinal cord. For a predefined w-value, segment weights are optimized within a few seconds on a DEC Alpha 3000. In practice, 5-10 w-values have to be tested, making optimization a less than 5 min procedure. This optimization procedure predicts...Continue Reading

References

Oct 1, 1990·Physics in Medicine and Biology·T BortfeldW Schlegel
Sep 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W De NeveJ Schelfhout

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Citations

Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K BratengeierM Flentje
Nov 22, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonas JohanssonBengt Glimelius
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·F ClausW De Neve
Nov 9, 2001·International Journal of Radiation Oncology, Biology, Physics·W De GersemW De Neve
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·UNKNOWN Intensity Modulated Radiation Therapy Collaborative Working Group
Sep 7, 1999·International Journal of Radiation Oncology, Biology, Physics·P U HugueninC Glanzmann
Jun 21, 2002·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Weining ZhenCharles A Enke
Apr 21, 2005·Medical Physics·Klaus Bratengeier
Dec 14, 2011·Radiation Oncology·Klaus BratengeierMichael Flentje
Mar 3, 2011·Medical Physics·Klaus BratengeierMichael Flentje
Feb 16, 2006·Medical Physics·Klaus Bratengeier
Nov 18, 2005·International Journal of Radiation Oncology, Biology, Physics·Eva K LeeIan Crocker
Jan 25, 2000·Cancer Treatment Reviews·N S Russell, H Bartelink
Nov 1, 2002·Physics in Medicine and Biology·Steven M CrooksLei Xing
Feb 1, 2003·Health Marketing Quarterly·Douglas G Nelson, Kent Byus
Jan 24, 2003·Physics in Medicine and Biology·Dietmar Georg, Bernhard Kroupa
Mar 10, 1999·Physics in Medicine and Biology·M Alber, F Nüsslin

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