3D domain swapping: a mechanism for oligomer assembly

Protein Science : a Publication of the Protein Society
M J BennettD Eisenberg

Abstract

3D domain swapping is a mechanism for forming oligomeric proteins from their monomers. In 3D domain swapping, one domain of a monomeric protein is replaced by the same domain from an identical protein chain. The result is an intertwined dimer or higher oligomer, with one domain of each subunit replaced by the identical domain from another subunit. The swapped "domain" can be as large as an entire tertiary globular domain, or as small as an alpha-helix or a strand of a beta-sheet. Examples of 3D domain swapping are reviewed that suggest domain swapping can serve as a mechanism for functional interconversion between monomers and oligomers, and that domain swapping may serve as a mechanism for evolution of some oligomeric proteins. Domain-swapped proteins present examples of a single protein chain folding into two distinct structures.

References

Jan 1, 1975·Annual Review of Biochemistry·I Zabin, M R Villarejo
Mar 1, 1975·Bacteriological Reviews·R J Collier
Feb 9, 1978·Nature·W Gilbert
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E Bibi, H R Kaback
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R PiccoliG D'Alessio
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Mar 1, 1991·Trends in Biochemical Sciences·G D'AlessioR Piccoli
Jan 1, 1989·Genomics·M TakahashiT Honjo
Oct 1, 1989·Protein Engineering·A V Finkelstein, J Janin
Jan 1, 1988·Progress in Biophysics and Molecular Biology·N H LubsenJ G Schoenmakers
Jan 1, 1988·Growth Factors·T R MizutaT Honjo
Aug 20, 1986·Journal of Molecular Biology·Y SatowD R Davies
Jul 15, 1988·The Biochemical Journal·R PiccoliG D'Alessio
Nov 5, 1988·Journal of Molecular Biology·J JaninC Chothia
May 6, 1986·Biochemistry·S F CarrollR J Collier
Jan 16, 1986·Nature·D Eisenberg, A D McLachlan
Sep 5, 1985·Journal of Molecular Biology·I Fita, M G Rossmann
Jul 20, 1973·Science·C B Anfinsen
Jan 1, 1982·Scandinavian Journal of Immunology. Supplement·G Gombos, D Aunis
Oct 15, 1983·Journal of Molecular Biology·G WistowT Blundell
Sep 1, 1995·Nature Structural Biology·S M GreenE E Lattman
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J MurrayR L Brady
Apr 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Jaenicke
Jan 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Raag, M Whitlow
Sep 1, 1994·Protein Science : a Publication of the Protein Society·S TrinklR Jaenicke
Sep 1, 1994·Protein Science : a Publication of the Protein Society·M J BennettD Eisenberg
Sep 1, 1994·Protein Science : a Publication of the Protein Society·M J Bennett, D Eisenberg
Mar 15, 1994·Structure·D A RozwarskiP A Karplus
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J BennettD Eisenberg

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Citations

Oct 10, 2001·Angewandte Chemie·Sean V. TaylorDonald Hilvert
Oct 17, 2002·The Anatomical Record·Catherine E Morris
Nov 1, 1996·Protein Science : a Publication of the Protein Society·D H ShinS W Suh
Jan 1, 1997·Protein Science : a Publication of the Protein Society·C J Tsai, R Nussinov
Jul 1, 1997·Protein Science : a Publication of the Protein Society·C J Tsai, R Nussinov
Jul 1, 1997·Protein Science : a Publication of the Protein Society·S PalmeR Jaenicke
Aug 1, 1997·Protein Science : a Publication of the Protein Society·B V NorledgeC Slingsby
Apr 16, 1998·Protein Science : a Publication of the Protein Society·D XuR Nussinov
Apr 16, 1998·Protein Science : a Publication of the Protein Society·S PalmeC Slingsby
Jul 9, 1998·Protein Science : a Publication of the Protein Society·G WrightC Slingsby
Jul 9, 1998·Protein Science : a Publication of the Protein Society·M HülsmeyerD Schomburg
Jul 31, 1998·Protein Science : a Publication of the Protein Society·S D Betts, J King
Mar 19, 1999·Protein Science : a Publication of the Protein Society·G MacBeathD Hilvert
Oct 7, 1998·Protein Science : a Publication of the Protein Society·A J ConstansJ T Lecomte
Dec 11, 1999·Cell Biochemistry and Biophysics·S KumarR Nussinov
Apr 4, 2006·Amino Acids·W HoehenwarterP R Jungblut
Jan 12, 2013·Cell Biochemistry and Biophysics·Olga N KorolevaValeriy L Drutsa
Dec 9, 2003·Journal of Molecular Biology·Jayasankar JastiT P Singh
Aug 11, 2004·Progress in Biophysics and Molecular Biology·Hans BloemendalAnnette Tardieu
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Michael W Parker, Susanne C Feil
Dec 24, 2003·Trends in Biotechnology·Michael Blaber
Dec 13, 2003·Tuberculosis·Clare V SmithJames C Sacchettini
Jan 29, 2000·FEBS Letters·S SorrentinoG D'Alessio
Oct 9, 2002·Journal of Molecular Biology·Marina Ramírez-Alvarado, Lynne Regan
Feb 19, 2003·Journal of Molecular Biology·Abuduaini AbulimitiZengyi Chang
Jul 16, 2003·Journal of Molecular Biology·Yves DehouckMarianne Rooman
Aug 30, 2003·Journal of Molecular Biology·Klára BriknarováKathryn R Ely
Sep 2, 2003·Journal of Molecular Biology·Palasingam PaaventhanPrasanna R Kolatkar
Mar 31, 1999·Progress in Biophysics and Molecular Biology·R Jaenicke
Dec 3, 1999·Progress in Biophysics and Molecular Biology·G D'Alessio
Jul 12, 1997·Lancet·R W Carrell, D A Lomas
Dec 31, 1998·Immunology Letters·R ZidovetzkiI Pecht
Nov 4, 2000·Biochimica Et Biophysica Acta·M TegoniC Cambillau
Apr 25, 2000·Plant Science : an International Journal of Experimental Plant Biology·K S JohansenS K Rasmussen
Mar 21, 2003·Biophysical Chemistry·Raphael ZidovetzkiIsrael Pecht
Feb 13, 2002·Current Opinion in Structural Biology·Marcia E Newcomer
Aug 7, 2002·Current Opinion in Structural Biology·Todd O Yeates, Jennifer E Padilla
Dec 1, 1996·Current Opinion in Structural Biology·M F Perutz
Feb 1, 1997·Current Opinion in Structural Biology·A V Finkelstein
Jun 1, 1997·Current Opinion in Structural Biology·J Heringa, W R Taylor
Jul 17, 1998·Current Opinion in Structural Biology·R B Russell, C P Ponting
Dec 23, 1999·Current Opinion in Structural Biology·V Fülöp, D T Jones

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