3D finite element model of aqueous outflow to predict the effect of femtosecond laser created partial thickness drainage channels

Lasers in Surgery and Medicine
Dongyul ChaiTibor Juhasz


Partial thickness drainage channels can be created with femtosecond lasers in the translucent sclera for the potential treatment of glaucoma. We present a 3D finite element model (FEM) that can predict the effect of these channels on aqueous humor (AH) outflow and intraocular pressure (IOP). A 3D model was developed based on a 2D model for the intact eye using COMSOL (Comsol, Inc., MA) finite element software. Different values of permeability were entered into the 3D model for the AH pathway and for the partial thickness channel. To obtain experimental data for model validation, one partial thickness channel was created in each of three enucleated rabbit eyes with a femtosecond laser tuned to 1.7 microm wavelength. Aqueous outflow rates were measured with the perfusion method before and after the laser treatments at different levels of IOP and then compared to IOP values predicted by the model. The experiments indicated that the rate of the AH outflow was increased in each of three eyes after the laser treatment. Assuming a constant rate of AH production the 3D model predicted IOP reductions ranging from 67.2% to 80.6% as the effect of the laser created channels. These predictions were in reasonable agreement with experimentall...Continue Reading


Feb 1, 1996·Ophthalmology·J SokolR Ritch
Sep 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·D W LuJ N Wu
Aug 15, 2002·Journal of Biomedical Optics·Zachary S SacksGerard A Mourau
Feb 2, 2006·Annals of Biomedical Engineering·Satish KumarArto Palkama
Aug 3, 2006·Journal of Vision·Eric C Huang, Victor H Barocas

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Sep 2, 2010·Lasers in Surgery and Medicine·Dongyul ChaiTibor Juhasz

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