3D genomic regulation of lncRNA and Xist in X chromosome

Seminars in Cell & Developmental Biology
Furong YanYiming Zeng

Abstract

Long noncoding RNAs (lncRNAs) act as important regulators in cardiovascular diseases, neural degenerative disease, or cancers, by localizing and spreading across chromatins. lncRNA can regulate the 3D architecture of the enhancer cluster at the target gene locus, relevant to analogous lncRNA-protein coding gene pairs. X inactive specific transcript (Xist) plays a critical role in the process and biological function of lncRNAs. The lncRNA Jpx, Xist activator, is a nonprotein-coding RNA transcribed from a gene within the X-inactivation center and acts as a numerator element to control X-chromosome number and activate Xist transcription by interacting with CCCTC-binding factor. Up-regulated lncRNA Xist initiates X chromosome inactivation process and attracts specific chromatin modifiers. A number of chromatin-modified factors interact with lncRNAs modify 3D genome architecture and mediate Xist function in embryo development. Thus, the regulation of lncRNAs in 3D genome progresses is the key mechanism of Xist, as a therapeutic potential for Xist associated diseases.

Citations

Apr 7, 2020·Science China. Life Sciences·Mengfan LiCheng Li
Jun 20, 2019·Nature Reviews. Endocrinology·Claus H GravholtNiels H Andersen
Aug 28, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan M Murillo-Maldonado, Juan R Riesgo-Escovar
Mar 7, 2021·International Journal of Molecular Sciences·Agnieszka Ruszkowska
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Wenlun WangLingyun Zhu
Jun 28, 2021·Gene·Fabrizio Bella, Salvatore Campo
Jul 24, 2021·Neurogenetics·Juan F Quesada-EspinosaJaime Sánchez Del Pozo

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