3D high-resolution diffusion-weighted MRI at 3T: Preliminary application in prostate cancer patients undergoing active surveillance protocol for low-risk prostate cancer

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Christopher NguyenDebiao Li

Abstract

To improve spatial resolution and image quality of diffusion-weighted (DW) MRI in detecting low-risk prostate cancer (lrPC) in patients undergoing active surveillance protocol (AS-PC), we propose the application of a diffusion-prepared balanced steady-state free precession (bSSFP) technique capable of multishot acquisition. Diffusion-prepared bSSFP was compared with single-shot DW echo planar imaging (SS-DW-EPI) at two prescribed resolutions (2.1 × 2.1 × 3.5mm(3) , 0.9 × 0.9 × 3.5 mm(3) ) in nine healthy subjects and nine AS-PC patients. Geometric distortion and susceptibility artifacts were quantitatively assessed in all subjects. In AS-PC patients, lesion detection via blinded multiparametric MRI including T1-weighted, T2-weighted, dynamic contrast-enhanced imaging, and along with either of two DW methods were evaluated against 12-point biopsy. Geometric distortion and susceptibility artifacts were significantly less for diffusion-prepared bSSFP at both prescribed spatial resolutions than SS-DW-EPI. Apparent diffusion coefficients of healthy prostate tissue were concordant between the two DW methods at both spatial resolutions. In AS-PC patients, multiparametric MRI with diffusion-prepared bSSFP had greater sensitivity (94%, ...Continue Reading

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Citations

Jul 22, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nima GilaniGlyn Johnson
Oct 29, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elisa RocciaIsabel Dregely
Apr 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohini Vidya ShankarIsabel Dregely
Oct 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Zhaohuan ZhangHolden H Wu
Nov 30, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jianmin YuanShreyas Vasanawala
Sep 4, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yoshiko R UenoTakamichi Murakami
Aug 21, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jesse K SandbergShreyas Vasanawala
Sep 30, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elisa RocciaIsabel Dregely
Sep 24, 2021·Medical Physics·Diego HernandoAli Pirasteh

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