3D high spectral and spatial resolution imaging of ex vivo mouse brain

Medical Physics
Sean FoxleyNancy Schwartz

Abstract

Widely used MRI methods show brain morphology both in vivo and ex vivo at very high resolution. Many of these methods (e.g., T2*-weighted imaging, phase-sensitive imaging, or susceptibility-weighted imaging) are sensitive to local magnetic susceptibility gradients produced by subtle variations in tissue composition. However, the spectral resolution of commonly used methods is limited to maintain reasonable run-time combined with very high spatial resolution. Here, the authors report on data acquisition at increased spectral resolution, with 3-dimensional high spectral and spatial resolution MRI, in order to analyze subtle variations in water proton resonance frequency and lineshape that reflect local anatomy. The resulting information compliments previous studies based on T2* and resonance frequency. The proton free induction decay was sampled at high resolution and Fourier transformed to produce a high-resolution water spectrum for each image voxel in a 3D volume. Data were acquired using a multigradient echo pulse sequence (i.e., echo-planar spectroscopic imaging) with a spatial resolution of 50 × 50 × 70 μm(3) and spectral resolution of 3.5 Hz. Data were analyzed in the spectral domain, and images were produced from the vari...Continue Reading

References

Oct 22, 1991·The Journal of Comparative Neurology·L Slomianka, F A Geneser
Feb 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S C ChuC S Springer
Jul 22, 1988·The Journal of Comparative Neurology·R C Green, M M Mesulam
Sep 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Doyle, P Mansfield
Sep 1, 1984·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Mansfield
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter
May 18, 1999·Archives of Neurology·G BartzokisJ Mintz
Apr 3, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W M SpeesJ J Ackerman
Feb 28, 2002·Radiology·G Allan JohnsonLaurence W Hedlund
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·G Allan JohnsonRobert R Maronpot
Nov 2, 2002·Journal of Magnetic Resonance Imaging : JMRI·Xiaobing FanGregory Karczmar
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weiliang DuGregory S Karczmar
Jan 17, 2004·Magnetic Resonance Imaging·O NattT Michaelis
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Mark HaackeJürgen R Reichenbach
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jung Hee LeeAlan P Koretsky
Jun 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander RauscherJürgen R Reichenbach
Sep 12, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anjum Ali Sharief, G Allan Johnson
Nov 1, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Mark HenkelmanJohn G Sled
Jan 19, 2007·NeuroImage·Shawn MikulaEdward G Jones
Jun 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeff H DuynMasaki Fukunaga
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·James StankiewiczRohit Bakshi
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yiping P DuJack H Simon
Aug 5, 2008·Physics in Medicine and Biology·S FoxleyG S Karczmar
Aug 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyGregory S Karczmar
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyGregory S Karczmar
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timothy M ShepherdStephen J Blackband
Jun 13, 2009·NeuroImage·Susann BoretiusJens Frahm
Jun 19, 2009·NMR in Biomedicine·Christof BaltesMarkus Rudin
Jun 23, 2009·Current Opinion in Neurology·Alexandra BadeaRobert W Williams
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiang He, Dmitriy A Yablonskiy
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karin ShmueliJeff H Duyn
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tie-Qiang LiJeff Duyn
Dec 26, 2009·NeuroImage·Yi Jiang, G Allan Johnson
Mar 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jongho LeeJeff H Duyn
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaowei ZhangRussell E Jacobs

❮ Previous
Next ❯

Citations

Aug 19, 2015·NMR in Biomedicine·Yu-Wen Chen, Dennis W Hwang
Apr 11, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tianyou XuKarla L Miller
Jul 18, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyKazutaka Takahashi
Oct 7, 2018·Journal of Magnetic Resonance Imaging : JMRI·Shiyang WangAytekin Oto
Aug 13, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyNarayanan Kasthuri
Aug 1, 2018·Scientific Reports·Linda C P CrotonMarcus J Kitchen
Mar 27, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott TrinklePatrick La Rivière

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Milica MedvedGregory S Karczmar
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Xiaobing FanGregory S Karczmar
© 2022 Meta ULC. All rights reserved