3D PLLA/ibuprofen composite scaffolds obtained by a supercritical fluids assisted process

Journal of Materials Science. Materials in Medicine
S CardeaE Reverchon

Abstract

The emerging next generation of engineered tissues is based on the development of loaded scaffolds containing bioactive molecules in order to control the cellular function or to interact on the surrounding tissues. Indeed, implantation of engineered biomaterials might cause local inflammation because of the host's immune response; thereby, the use of anti-inflammatory agents, whether steroidal or nonsteroidal is required. One of the most important stages of tissue engineering is the design and the generation of a porous 3D structure, with high porosity, high interconnectivity and homogenous morphology. Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds, but they suffer several limitations. In this study, for the first time, the possibility of generating 3D polymeric scaffolds loaded with an active compound by supercritical freeze extraction process is evaluated; this innovative process combines the advantages of the thermally induced phase separation process and of the supercritical carbon dioxide drying. Poly-L-lactid acid/ibuprofen composite scaffolds characterized by a 3D geometry, micrometric cellular structures and wrinkled pores walls have been obtained; moreover, homoge...Continue Reading

References

Feb 1, 1993·Journal of Biomedical Materials Research·A G MikosR Langer
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Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Gerd Brunner
Oct 17, 2013·Journal of Materials Science. Materials in Medicine·S CardeaE Reverchon

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Citations

Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Stefano CardeaErnesto Reverchon
Feb 4, 2016·British Medical Bulletin·Lucia BaldinoErnesto Reverchon
Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Oct 22, 2020·BioMed Research International·Lili HeZhi-Xiang Yuan

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