3D printed capsules for quantitative regional absorption studies in the GI tract

International Journal of Pharmaceutics
Derrick M SmithAdam T Procopio

Abstract

Drug development is a long process which requires careful evaluation of the drug substance (active pharmaceutical ingredient, API), drug product (tablet, capsule etc.) and the bioperformance (both pre-clinical and clinical) before testing the efficacy of the final dosage form. The earliest assessment of a new drug substance requires an understanding of the safety and clinical performance (Phase 1) wherein faster processes (like on-site formulation strategy) have been set in place for quick clinical read-outs. One key gap that exists in this early assessment is the ability to evaluate modified release drug products. Here, an additive manufacturing approach is used to prepare polyvinyl alcohol (PVA) capsule shells using 3D printing (3DP), where the shells can be filled with either a solid or a liquid vehicle containing the API. In this work we demonstrate how we can delay the release of the API from the printed capsules allowing us to evaluate regional absorption in pre-clinical studies. By using 3DP, a new method to provide a series of release profiles is demonstrated, where the induction time of a delayed burst release is controlled by the wall thicknesses of printed capsules. New hanging baskets were also designed and 3D print...Continue Reading

Citations

Jun 11, 2019·Pharmaceutical Development and Technology·E B SoutoA M Silva
Mar 25, 2020·Drug Delivery and Translational Research·Manisha PandeyBapi Gorain
Jun 9, 2020·Expert Opinion on Drug Delivery·Georgios K EleftheriadisDimitrios G Fatouros
Jul 4, 2020·Drug Development and Industrial Pharmacy·Ivana Cotabarren, Loreana Gallo
Jan 15, 2019·Current Pharmaceutical Design·Mohammed S AlgahtaniJaved Ahmad
Dec 7, 2018·Advanced Materials·Kun LiangJean-Christophe Leroux
Jan 19, 2021·AAPS PharmSciTech·Vanessa Marcia Vaz, Lalit Kumar
Oct 10, 2020·Journal of Pharmaceutical Sciences·Manjusha AnnajiR Jayachandra Babu
Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan
May 10, 2021·Advanced Drug Delivery Reviews·Iria Seoane-ViañoAlvaro Goyanes
Nov 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sylvain CailleauxIan Soulairol
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen
Oct 4, 2020·International Journal of Pharmaceutics·Alice MelocchiAhmed Zidan

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