3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds

International Journal of Pharmaceutics
Forough HafeziJoshua S Boateng

Abstract

Recently, various additive manufacturing (3D printing) approaches have been employed to fabricate dressings such as film scaffolds that possess well defined architecture and orientation at the micro level. In this study, crosslinked chitosan (CH) based film matrices were prepared using 3D printing with genipin (GE) as a crosslinker, with glycerol (GLY) and poly ethylene glycol (PEG) as plasticizer. The 3D printed films were functionally characterized using (tensile, fluid handling, mucoadhesion, drug dissolution, morphological properties and cell viability as well physico-chemical characterization using scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. CH-GE-PEG600 3D printed films having the ratio of 1:1 polymer: plasticizer was selected due to their appropriate flexibility. Fourier transform infrared results showed intermolecular interaction between CH, GE and PEG which was confirmed by X-ray diffraction showing amorphous matrix structure. In vitro mucoadhesion studies of CH-GE-PEG600 films showed the capability of the 3D printed film to adhere to the epithelial surface. Scanning electron microscopy images showed that the surface of the plasticised films were smooth indicating conten...Continue Reading

Citations

Oct 1, 2020·3D Printing in Medicine·Mina BoshraAndy Pan
Aug 7, 2020·Materials·Katarzyna Wegrzynowska-DrzymalskaMarta Ziegler-Borowska
Nov 17, 2020·International Journal of Biological Macromolecules·Kamel R ShoueirMaged El-Kemary
Nov 19, 2020·Polymers·Mior Muhammad Amirul ArifMohd Heikal Mohd Yunus
Jan 21, 2021·Marine Drugs·Georgia MichailidouDimitrios N Bikiaris
Mar 16, 2021·Analytical Chemistry·Yuqiu WangBingbing Gao
Mar 14, 2021·Carbohydrate Polymers·Mina RajabiM Azam Ali
May 1, 2021·Pharmaceuticals·Paula Gabriela ManitaManoli Igartua
Jun 27, 2021·Advanced Healthcare Materials·Mojtaba Farahani, Abbas Shafiee
Jul 24, 2021·International Journal of Biological Macromolecules·Xiaoxue WangBo Chi
Mar 23, 2021··Hanif AssyarifyArindha R. Pramesti

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