3D-printed microfluidic automation

Lab on a Chip
Anthony K AuAlbert Folch

Abstract

Microfluidic automation - the automated routing, dispensing, mixing, and/or separation of fluids through microchannels - generally remains a slowly-spreading technology because device fabrication requires sophisticated facilities and the technology's use demands expert operators. Integrating microfluidic automation in devices has involved specialized multi-layering and bonding approaches. Stereolithography is an assembly-free, 3D-printing technique that is emerging as an efficient alternative for rapid prototyping of biomedical devices. Here we describe fluidic valves and pumps that can be stereolithographically printed in optically-clear, biocompatible plastic and integrated within microfluidic devices at low cost. User-friendly fluid automation devices can be printed and used by non-engineers as replacement for costly robotic pipettors or tedious manual pipetting. Engineers can manipulate the designs as digital modules into new devices of expanded functionality. Printing these devices only requires the digital file and electronic access to a printer.

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Citations

Feb 9, 2016·Angewandte Chemie·Anthony K AuAlbert Folch
Sep 26, 2015·Biosensors & Bioelectronics·Karteek KadimisettyJames F Rusling
Jan 9, 2016·RSC Advances·Hua GongGregory P Nordin
Mar 31, 2016·Lab on a Chip·Dishit P ParekhMichael D Dickey
Apr 22, 2016·Lab on a Chip·Nirveek BhattacharjeeAlbert Folch
Sep 12, 2015·PloS One·Martin D BrennanDavid T Eddington
May 6, 2016·Lab on a Chip·Sidra WaheedMichael C Breadmore
May 14, 2016·Lab on a Chip·Ian S Kinstlinger, Jordan S Miller
May 18, 2016·Pharmaceutical Research·Timothy HammondHolly Birdsall
Jul 19, 2016·Lab on a Chip·Mitchell Boyd-MossKhashayar Khoshmanesh
Sep 13, 2016·Analytical Methods : Advancing Methods and Applications·Chengpeng ChenR Scott Martin
Aug 16, 2016·PloS One·Steven J KeatingNeri Oxman
Dec 31, 2015·PloS One·William G PatrickDavid S Kong
Nov 26, 2016·Sensors·Mohammed-Baker HabhabJoe Fujiou Lo
Apr 5, 2017·Lab on a Chip·Nicolas BertinPhilippe Marmottant
Jul 14, 2017·Lab on a Chip·Ho Nam ChanHongkai Wu
Mar 20, 2018·Lab on a Chip·Yuan-Sheng LeeAlbert Folch
Mar 30, 2018·PloS One·Peter G ShanklesScott T Retterer
Apr 14, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Romilde ManzoniFrancesc Posas
Aug 25, 2017·Biofabrication·Louis Jun Ye OngYi-Chin Toh
Sep 2, 2017·Lab on a Chip·Yongha Hwang, Rob N Candler
Oct 4, 2018·Lab on a Chip·Jia Ming ZhangHuiling Duan
Oct 31, 2015·Scientific Reports·Krisna C BhargavaNoah Malmstadt
Jun 6, 2019·Annual Review of Biomedical Engineering·Arman NaderiAlbert Folch
Jun 19, 2019·Lab on a Chip·Andrew C LamontRyan D Sochol
Jul 25, 2019·Lab on a Chip·Abdullah T AlsharhanRyan D Sochol
Nov 7, 2019·Micromachines·Jia Ming ZhangHuiling Duan
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Jun 21, 2016·Biofabrication·Stephanie KnowltonSavas Tasoglu
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Jun 3, 2016·Nanotechnology·Gregory W BishopJames F Rusling

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