3D-Printed PCL/rGO Conductive Scaffolds for Peripheral Nerve Injury Repair

Artificial Organs
Sanjairaj VijayavenkataramanJerry Ying Hsi Fuh

Abstract

The incidence of peripheral nerve injuries is on the rise and the current gold standard for treatment of such injuries is nerve autografting. Given the severe limitations of nerve autografts which include donor site morbidity and limited supply, neural guide conduits (NGCs) are considered as an effective alternative treatment. Conductivity is a desired property of an ideal NGC. Reduced graphene oxide (rGO) possesses several advantages in addition to its conductive nature such as high surface area to volume ratio due to its nanostructure and has been explored for its use in tissue engineering. However, most of the works reported are on traditional 2D culture with a layer of rGO coating, while the native tissue microenvironment is three-dimensional. In this study, PCL/rGO scaffolds are fabricated using electrohydrodynamic jet (EHD-jet) 3D printing method as a proof of concept study. Mechanical and material characterization of the printed PCL/rGO scaffolds and PCL scaffolds was done. The addition of rGO results in softer scaffolds which is favorable for neural differentiation. In vitro neural differentiation studies using PC12 cells were also performed. Cell proliferation was higher in the PCL/rGO scaffolds than the PCL scaffolds....Continue Reading

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Citations

Dec 12, 2018·Neural Regeneration Research·Pei-Xun ZhangBao-Guo Jiang
Nov 22, 2019·Frontiers in Bioengineering and Biotechnology·Sanjairaj VijayavenkataramanWen Feng Lu
Jan 23, 2020·Artificial Organs·Paul S Malchesky
Mar 21, 2020·Journal of Biomedical Materials Research. Part a·Qing LiDi Lu
Nov 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xingxing FangPeixun Zhang
Dec 4, 2020·Artificial Organs·Qingshan LongFeng Xu
Feb 8, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Noah Z LairdAliasger K Salem
Feb 18, 2021·Tissue Engineering. Part B, Reviews·Omar A SelimDeepak M Kalaskar
Feb 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhiqiang HuangHong Li
Jun 3, 2021·Nanomaterials·Giacomo DamonteOrietta Monticelli
Jul 3, 2021·Burns and Trauma·Yulan HuangMaling Gou

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