3D printing and coating to fabricate a hollow bullet-shaped implant with porous surface for controlled cytoxan release

International Journal of Pharmaceutics
Ning YangShengrong Guo

Abstract

Intratumoral implants have aroused great interests for local chemotherapy of cancer, however, how to efficiently control drug release from implants is still a great challenge. Herein, we designed and prepared a new hollow bullet-shaped implant with porous surface by 3D printing, loaded chemotherapeutic agent cytoxan (CTX) with tetradecyl alcohol or lecithin as matrix and coated it with poly (lactic acid) to obtain a CTX implant, which has a highly tuned drug release property with a drug release time from 4 h to more than 1 month. The drug release from the implant can be easily controlled by changing pore sizes, kinds of matrices, and coating thickness.

Citations

Sep 5, 2019·AAPS PharmSciTech·Kawther Khalid AhmedAliasger K Salem
Sep 21, 2020·Clinical Oral Investigations·Gunpreet OberoiHermann Agis
Aug 17, 2019·Journal of Clinical Medicine·Elie AkouryDerek H Rosenzweig
Feb 5, 2021·International Journal of Pharmaceutics·Athina LiaskoniClive J Roberts
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Petra AranyIldikó Bácskay
May 22, 2021·Advanced Drug Delivery Reviews·Moe ElbadawiAbdul W Basit
Sep 22, 2021·The Thoracic and Cardiovascular Surgeon·Ganwei LiuGuanchao Jiang

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