3D printing and modelling of customized implants and surgical guides for non-human primates

Journal of Neuroscience Methods
Xing ChenPieter R Roelfsema

Abstract

Primate neurobiologists use chronically implanted devices such as pedestals for head stabilization and chambers to gain access to the brain and study its activity. Such implants are skull-mounted, and made from a hard, durable material, such as titanium. Here, we present a low-cost method of creating customized 3D-printed cranial implants that are tailored to the anatomy of individual animals. We performed pre-surgical computed tomography (CT) and magnetic resonance (MR) scans to generate three-dimensional (3D) models of the skull and brain. We then used 3D modelling software to design implantable head posts, chambers, and a pedestal anchorage base, as well as craniotomy guides to aid us during surgery. Prototypes were made from plastic or resin, while implants were 3D-printed in titanium. The implants underwent post-processing and received a coating of osteocompatible material to promote bone integration. Their tailored fit greatly facilitated surgical implantation, and eliminated the gap between the implant and the bone. To date, our implants remain robust and well-integrated with the skull. Commercial-off-the-shelf solutions typically come with a uniform, flat base, preventing them from sitting flush against the curved surfa...Continue Reading

Citations

Jun 1, 2018·International Journal of Molecular Sciences·Bartłomiej WysockiWojciech Święszkowski
Oct 8, 2019·Tissue Engineering. Part B, Reviews·Dan WangGregory M Cooper
Jun 5, 2020·Journal of Neural Engineering·Chia-Han ChiangJonathan Viventi
Mar 6, 2019·Orthopaedic Surgery·Xiao-Lei GuoZhong Lu
Aug 5, 2020·Nature Biomedical Engineering·Nir Even-ChenKrishna V Shenoy
Aug 28, 2020·Frontiers in Neuroscience·Eduardo FernándezPablo González-López
Apr 26, 2019·Journal of Healthcare Engineering·Anna AimarBernardo Innocenti
Nov 3, 2020·NeuroImage·Mark J Prescott, Colline Poirier
Dec 18, 2020·Frontiers in Veterinary Science·Gunpreet OberoiEwald Unger
Apr 26, 2018·Journal of Neuroscience Methods·Jackson D BlondeJulio C Martinez-Trujillo
Jul 15, 2021·Cell Reports·Jeffrey D WalkerNicholas G Hatsopoulos
Oct 16, 2021·Current Biology : CB·Rob R M TeeuwenPieter R Roelfsema
Oct 8, 2021·Journal of the American Association for Laboratory Animal Science : JAALAS

❮ Previous
Next ❯

Methods Mentioned

BETA
cochlear implant

Software Mentioned

MeshLab STL
3D
OsiriX Lite
MeshLab
matic ( Materialise )
InVesalius
Mac
Slicer
DICOM
LaTeX script

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomedizinische Technik. Biomedical Engineering
S FelberW Judmaier
Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
André Luiz JardiniPaulo Kharmandayan
International Journal of Oral and Maxillofacial Surgery
R BoscJ-P Meningaud
© 2022 Meta ULC. All rights reserved