3D printing of a wearable personalized oral delivery device: A first-in-human study

Science Advances
Kun LiangJean-Christophe Leroux

Abstract

Despite the burgeoning interest in three-dimensional (3D) printing for the manufacture of customizable oral dosage formulations, a U.S. Food and Drug Administration-approved tablet notwithstanding, the full potential of 3D printing in pharmaceutical sciences has not been realized. In particular, 3D-printed drug-eluting devices offer the possibility for personalization in terms of shape, size, and architecture, but their clinical applications have remained relatively unexplored. We used 3D printing to manufacture a tailored oral drug delivery device with customizable design and tunable release rates in the form of a mouthguard and, subsequently, evaluated the performance of this system in the native setting in a first-in-human study. Our proof-of-concept work demonstrates the immense potential of 3D printing as a platform for the development and translation of next-generation drug delivery devices for personalized therapy.

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Citations

Feb 13, 2019·Drug Development and Industrial Pharmacy·Pan TianYan-Zhong Chen
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Methods Mentioned

BETA
differential scanning calorimetry
x-ray powder diffraction

Software Mentioned

Exponent
TA Instruments Universal Analysis 2000
Simplify3D
Blender
Autodesk Netfabb 2015
Autodesk Netfabb
GraphPad Prism

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