3D Printing of Conductive Tissue Engineering Scaffolds Containing Polypyrrole Nanoparticles with Different Morphologies and Concentrations

Materials
Chunyang MaXiaodan Sun

Abstract

Inspired by electrically active tissues, conductive materials have been extensively developed for electrically active tissue engineering scaffolds. In addition to excellent conductivity, nanocomposite conductive materials can also provide nanoscale structure similar to the natural extracellular microenvironment. Recently, the combination of three-dimensional (3D) printing and nanotechnology has opened up a new era of conductive tissue engineering scaffolds exhibiting optimized properties and multifunctionality. Furthermore, in the case of two-dimensional (2D) conductive film scaffolds such as periosteum, nerve membrane, skin repair, etc., the traditional preparation process, such as solvent casting, produces 2D films with defects of unequal bubbles and thickness frequently. In this study, poly-l-lactide (PLLA) conductive scaffolds incorporated with polypyrrole (PPy) nanoparticles, which have multiscale structure similar to natural tissue, were prepared by combining extrusion-based low-temperature deposition 3D printing with freeze-drying. Furthermore, we creatively integrated the advantages of 3D printing and solvent casting and successfully developed a 2D conductive film scaffold with no bubbles, uniform thickness, and good st...Continue Reading

References

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Citations

Jan 18, 2020·International Journal of Molecular Sciences·Aziz EftekhariMagali Cucchiarini
Dec 17, 2020·Acta Biomaterialia·Emi A KiyotakeMichael S Detamore
Feb 6, 2021·Polymers·Sandya Shiranthi AthukoralaNamita Roy Choudhury
Jun 3, 2021·Materials·Javier MonteroCristina Gómez-Polo
Aug 30, 2021·Acta Biomaterialia·Hamid EsmaeiliMehdi Nikkhah
Jan 30, 2020·Journal of Clinical Orthopaedics and Trauma·Abid HaleemRajiv Suman

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Methods Mentioned

BETA
scanning electron microscopy
transmission electron microscopy
electron microscopy

Software Mentioned

BioScaffolder
Gesim Robotics
3D
SPSS Statistics

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