3D Printing of Porous Scaffolds with Controlled Porosity and Pore Size Values

Materials
Irene Buj-CorralOriol Petit-Rojo

Abstract

3D printed scaffolds can be used, for example, in medical applications for simulating body tissues or for manufacturing prostheses. However, it is difficult to print porous structures of specific porosity and pore size values with fused deposition modelling (FDM) technology. The present paper provides a methodology to design porous structures to be printed. First, a model is defined with some theoretical parallel planes, which are bounded within a geometrical figure, for example a disk. Each plane has randomly distributed points on it. Then, the points are joined with lines. Finally, the lines are given a certain volume and the structure is obtained. The porosity of the structure depends on three geometrical variables: the distance between parallel layers, the number of columns on each layer and the radius of the columns. In order to obtain mathematical models to relate the variables with three responses, the porosity, the mean of pore diameter and the variance of pore diameter of the structures, design of experiments with three-level factorial analysis was used. Finally, multiobjective optimization was carried out by means of the desirability function method. In order to favour fixation of the structures by osseointegration, p...Continue Reading

References

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Citations

Nov 20, 2019·Annals of Biomedical Engineering·A Tejo-OteroF Fenollosa-Artés
Dec 12, 2019·Biofabrication·Ashley A ArmstrongAmy J Wagoner Johnson
Feb 23, 2020·Pharmaceutics·Pariksha Jolene KondiahViness Pillay
May 18, 2020·Journal of Biomedical Materials Research. Part a·Bijan AbarJennifer L West
Sep 21, 2020·Clinical Oral Investigations·Gunpreet OberoiHermann Agis
Nov 6, 2018·Materials·Eva María Rubio, Ana María Camacho
Apr 23, 2021·Acta Biomaterialia·Yimeng LiLu Wang
Jun 20, 2021·The AAPS Journal·Ryan IvoneJie Shen
Aug 27, 2021·Bioengineering·Luana A OsórioRuth E Mackay

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Methods Mentioned

BETA
bioprinting
X-ray
atomic force microscopy

Software Mentioned

VG Studio Max
Rhinoceros
Cura
MATLAB
Grasshopper

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