3D Printing of Strontium Silicate Microcylinder-Containing Multicellular Biomaterial Inks for Vascularized Skin Regeneration.

Advanced Healthcare Materials
Jingge MaChengtie Wu

Abstract

The reconstruction of dermal blood vessels is essential for skin regeneration process. However, the lack of vascular structure, insufficient angiogenesis induction, and ineffective graft-host anastomosis of the existing skin substitutes are major bottle-necks for permanent skin replacement in tissue engineering. In this study, the uniform strontium silicate (SS) microcylinders are successfully synthesized and integrated into the biomaterial ink to serve as stable cell-induced factors for angiogenesis, and then a functional skin substitute based on a vascularization-induced biomimetic multicellular system is prepared via a "cell-writing" bioprinting technology. With an unprecedented combination of vascularized skin-mimicking structure and vascularization-induced function, the SS-containing multicellular system exhibits outstanding angiogenic activity both in vitro and in vivo. As a result, the bioprinted skin substitutes significantly accelerate the healing of both acute and chronic wounds by promoting the graft-host integration and vascularized skin regeneration in three animal models. Therefore, the study provides a referable strategy to fabricate biomimetic multicellular constructs with angiogenesis-induced function for regen...Continue Reading

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I V YannasG F Murphy
May 14, 1993·Science·R Langer, J P Vacanti
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A F BlackF A Auger
Aug 5, 2000·Burns : Journal of the International Society for Burn Injuries·M LossV E Meyer
May 29, 2002·Human Gene Therapy·Marcela Del RioJosé Luis Jorcano
Mar 11, 2003·The Journal of Biological Chemistry·Kanyan XiaoAndrew P Kowalczyk
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jun 5, 2003·Nature Medicine·Christopher W Pugh, Peter J Ratcliffe
Nov 19, 2003·Advanced Drug Delivery Reviews·Zbigniew Ruszczak
Jul 9, 2005·Nature Materials·Scott J Hollister
Nov 18, 2005·Lancet·Vincent Falanga
Sep 14, 2006·Tissue Engineering·Matthias W LaschkeMichael D Menger
Jan 26, 2007·Journal of the Royal Society, Interface·Anthony D Metcalfe, Mark W J Ferguson
Aug 11, 2007·Biomaterials·Anthony D Metcalfe, Mark W J Ferguson
May 16, 2008·Nature·Geoffrey C GurtnerMichael T Longaker
Jul 1, 2008·Trends in Biotechnology·Jeroen RouwkemaClemens A van Blitterswijk
Jan 30, 2009·Biomaterials·Vladimir MironovRoger R Markwald
Feb 2, 2011·Advanced Drug Delivery Reviews·C James KirkpatrickRonald E Unger
Mar 18, 2011·Biomaterials·Lutz-Christian GerhardtAldo R Boccaccini
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
May 3, 2013·Nano Letters·Manu S MannoorMichael C McAlpine
Feb 20, 2014·Advanced Materials·David B KoleskyJennifer A Lewis
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Sep 18, 2014·Dermatology : International Journal for Clinical and Investigative Dermatology·Nadja ZöllerRoland Kaufmann
Dec 5, 2014·Science Translational Medicine·Sabine A EmingMarjana Tomic-Canic
May 6, 2015·The British Journal of Dermatology·N AliH R Rezvani
Jan 3, 2016·Biotechnology Advances·Christian MandryckyDeok-Ho Kim
Jun 23, 2016·Advanced Healthcare Materials·Hasan E AbaciAngela M Christiano
Jul 22, 2016·Critical Reviews in Biotechnology·Florian S FruehMatthias W Laschke
Dec 6, 2016·Biofabrication·Nieves CuboJose L Jorcano
Dec 16, 2016·Advanced Healthcare Materials·Léa J PourchetChristophe A Marquette

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