3D screen printing - An innovative technology for large-scale manufacturing of pharmaceutical dosage forms.

International Journal of Pharmaceutics
Daniel MoldenhauerAchim Schneeberger

Abstract

Three-dimensional (3D) screen printing was used to fabricate oral dosage forms of different geometry and size. The paste required as starting material for the 3D screen printing process was designed for delayed release and contained the model drug paracetamol (acetaminophen). A prototype screen printing unit was used to fabricate different tablets in a single production process. The resulting tablets were produced with three different sizes and designed geometries (disk, donut, cuboid, oval and grid). Investigation of size and mass of the individual tablets demonstrated high uniformity within the various groups of tablets. Further characterization of their physical properties, such as breaking force and friability, yielded results comparing favorably to conventionally produced tablets. Finally, drug release tests in artificial gastric media showed paracetamol release to depend on the surface-area-to-volume ratio. In conclusion, the study shows the potential of 3D screen printing to fabricate more complex oral dosage forms in the setting of mass production with high reproducibility.

Citations

Feb 11, 2021·Nanomaterials·Keerti JainSwaran Jeet Singh Flora
May 22, 2021·Advanced Drug Delivery Reviews·Moe ElbadawiAbdul W Basit
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Related Papers

Health Services Journal
Matt DexterKeith Grimes
Current Pharmaceutical Design
AfsanaKeerti Jain
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Marijana Madžarević, Svetlana Ibrić
© 2021 Meta ULC. All rights reserved