3D-specific absorption rate estimation from high-intensity focused ultrasound sonications using the Green's function heat kernel

Medical Physics
Nicholas J FreemanDennis L Parker

Abstract

To evaluate a numerical inverse Green's function method for deriving specific absorption rates (SARs) from high-intensity focused ultrasound (HIFU) sonications using tissue parameters (thermal conductivity, specific heat capacity, and mass density) and three-dimensional (3D) magnetic resonance imaging (MRI) temperature measurements. SAR estimates were evaluated using simulations and MR temperature measurements from HIFU sonications. For simulations, a "true" SAR was calculated using the hybrid angular spectrum method for ultrasound simulations. This "true" SAR was plugged into a Pennes bioheat transfer equation (PBTE) solver to provide simulated temperature maps, which were then used to calculate the SAR estimate using the presented method. Zero mean Gaussian noise, corresponding to temperature precisions between 0.1 and 2.0°C, was added to the temperature maps to simulate a variety of in vivo situations. Experimental MR temperature maps from HIFU sonications in a gelatin phantom monitored with a 3D segmented echo planar imaging MRI pulse sequence were also used. To determine the accuracy of the simulated and phantom data, we reconstructed temperature maps by plugging in the estimated SAR to the PBTE solver. In both simulations...Continue Reading

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