3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors.

Frontiers in Molecular Biosciences
Noriyoshi Manabe, Yoshiki Yamaguchi

Abstract

Humans and other mammals resist exogenous pathogens by recognizing them as non-self. How do they do this? The answer lies in the recognition by mammalian lectin receptors of glycans usually found on the surface of pathogens and whose chemical structure is species-specific. Some glycan components, such as galactofuranose, only occur in microbes, and is the principal means by which mammalian lectin receptors recognize non-self. Several lectins may function together as pattern recognition receptors to survey the infecting pathogen before the adaptive immune system is invoked. Most lectins have primary and secondary monosaccharide-binding sites which together determine the specificity of a receptor toward microbial glycans. There may also be a hydrophobic groove alongside the sugar binding sites that increases specificity. Another elaboration is through oligomerization of lectin domains with defined spacing and arrangement that creates high-affinity binding towards multiply-presented glycans on microbes. Microbe-specific polysaccharides may arise through unique sugar linkages. Specificity can come from mammalian receptors possessing a shallow binding site and binding only internal disaccharide units, as in the recognition of mannan...Continue Reading

References

Jul 15, 1997·The Biochemical Journal·R Wallis, K Drickamer
Feb 19, 2002·The Journal of Biological Chemistry·Kenneth K-S NgWilliam I Weis
May 3, 2007·Protein Science : a Publication of the Protein Society·James BrownE Yvonne Jones
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sho YamasakiTakashi Saito
Dec 17, 2009·The Journal of Experimental Medicine·Eri IshikawaSho Yamasaki
Feb 26, 2010·The Journal of Biological Chemistry·Hadar FeinbergWilliam I Weis
Jul 2, 2010·Sub-cellular Biochemistry·Alba Silipo, Antonio Molinaro
Nov 30, 2010·Biochemical and Biophysical Research Communications·Mayumi KanagawaYoshiki Yamaguchi
May 15, 2012·Bioorganic & Medicinal Chemistry·Hiroshi TanakaTakashi Takahashi
Aug 21, 2013·The Journal of Biological Chemistry·Hadar FeinbergKurt Drickamer
Dec 3, 2013·Glycoconjugate Journal·Shinya HanashimaYoshiki Yamaguchi
Mar 7, 2014·International Journal of Molecular Sciences·Masamichi Nagae, Yoshiki Yamaguchi
May 3, 2014·The Journal of Biological Chemistry·Mayumi KanagawaYoshiki Yamaguchi
Apr 29, 2015·Chembiochem : a European Journal of Chemical Biology·Shinya HanashimaYoshiki Yamaguchi
Jul 7, 2015·Nature Structural & Molecular Biology·Darryl A WesenerLaura L Kiessling
Aug 25, 2015·The Journal of Biological Chemistry·Ryoko KiyotakeSho Yamasaki
Jun 29, 2016·Journal of Structural Biology·Anika ReinhardtPeter H Seeberger
Nov 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Joakim H BergströmGunnar C Hansson
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alexey V KostarnoyAlexander L Gintsburg
Apr 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Masahiro NagataSho Yamasaki
Jun 28, 2017·The Journal of Biological Chemistry·Hadar FeinbergMaureen E Taylor
Apr 10, 2018·Biochimica Et Biophysica Acta. General Subjects·Fumi OtaNaoyuki Taniguchi
Jan 19, 2019·Carbohydrate Research·Yoshimi KanieOsamu Kanie
Jun 12, 2019·Glycobiology·Sriram NeelameghamUNKNOWN SNFG Discussion Group
Jan 14, 2020·Journal of the American Chemical Society·Caitlin M McMahonLaura L Kiessling
Aug 17, 2020·The Journal of Experimental Medicine·Miyako TanakaTakayoshi Suganami
Feb 1, 2021·The Journal of Biological Chemistry·Zakaria OmahdiSho Yamasaki

❮ Previous
Next ❯

Software Mentioned

SP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.