3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects

Academic Radiology
Ravinder R RegatteR Reddy

Abstract

To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI). All the MRI experiments were performed on a 1.5 T whole-body GE Signa clinical scanner using a custom built 15-cm diameter transmit-receive quadrature birdcage radiofrequency coil. The T(1rho)-prepared magnetization was imaged with a three-dimensional gradient-echo pulse sequence pre-encoded with a three-pulse cluster consisting of two hard 90 degrees pulses and a low power spin-lock pulse. Quantitative T(1rho) relaxation maps of asymptomatic (n = 8 males), and six symptomatic human volunteers (four men, two women) were computed using a appropriate signal expression. All six symptomatic volunteers showed elevation in T(1rho) relaxation times when compared with asymptomatic subjects. In symptomatic population, the T(1rho) relaxation times varied from 63 +/- 4 ms to 95 +/- 12 ms (mean +/- standard deviation) depending on the degree of cartilage degeneration. The increase in T(1rho) of symptomatic population was statistically significant (n = 6, P <.002) when compared with corresponding asymptomatic popul...Continue Reading

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Citations

Oct 4, 2007·Skeletal Radiology·Renata La Rocca VieiraRavinder Regatte
Aug 19, 2011·Skeletal Radiology·Carl S Winalski, Prabhakar Rajiah
Mar 23, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Joshua D AuerbachDawn M Elliott
Jul 27, 2011·The Journal of Physical Chemistry. B·Jiadi XuAyyalusamy Ramamoorthy
Oct 14, 2008·Seminars in Musculoskeletal Radiology·Ravinder R Regatte, Mark E Schweitzer
Nov 18, 2008·Sports Medicine and Arthroscopy Review·Hollis G PotterDarryl B Sneag
Nov 9, 2012·Journal of the Royal Society, Interface·Deva D Chan, Corey P Neu
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Yuanyuan WangFlavia M Cicuttini
Apr 3, 2008·The Journal of Bone and Joint Surgery. American Volume·An M NguyenDawn M Elliott
May 17, 2014·PloS One·Anup SinghRavinder Reddy
Sep 15, 2014·Current Rheumatology Reports·Stephen J MatzatGarry E Gold
Jul 23, 2011·Radiology·Frank W RoemerAli Guermazi
Aug 16, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick SchuenkeMoritz Zaiss
May 6, 2017·World Journal of Orthopedics·Benjamin S KesterRan Schwarzkopf
Dec 29, 2010·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yukihisa TakayamaHiroshi Honda
Nov 10, 2006·European Radiology·Thomas M LinkKlaus Woertler
Jan 20, 2016·Skeletal Radiology·Sven NebelungDaniel Truhn
Aug 23, 2017·AJR. American Journal of Roentgenology·Andrew L ChangHiroshi Yoshioka

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