3DinSight: an integrated relational database and search tool for the structure, function and properties of biomolecules

Bioinformatics
J AnAkinori Sarai

Abstract

Although a large amount of information on the structure, function and properties of biomolecules is becoming available, it is difficult to understand the relationship between them. Thus, we have attempted to create an integrated relational database, search and visualization tool, 3DinSight, to help researchers to gain insight into their relationship. We have gathered data on the structure, function and properties of biomolecules, and implemented them into a relational database system. The structural data contain several subset data such as protein homologues, protein-DNA complex, in order to enable searching within a specific class of data. The functional data include motif sequence and mutation data of proteins. Also, various amino acid properties are implemented as a relational table. The World Wide Web (WWW) interfaces enable users to carry out various kinds of searches among these data. The locations of motif sequences and mutations are automatically mapped on the structure, and visualized in three-dimensional (3D) space by interactive viewers, VRML (Virtual Reality Modeling Language) and RasMol. In the case of VRML, the mapped 3D objects are hyper-linked to the corresponding document data. Also, amino acid properties, link...Continue Reading

Citations

Feb 1, 2003·Journal of Molecular Biology·Judith GüntherGerhard Klebe
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Dec 19, 2003·Nucleic Acids Research·K Abdulla BavaAkinori Sarai
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Jan 8, 2021·BMC Microbiology·Nathaly Andrea Montenegro BenavidesAdriana Bernal

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