3H]-monoamine uptake inhibition properties of kava pyrones

Planta medica
U SeitzJ Gleitz

Abstract

Three kava pyrones, the natural compounds (+)-methysticine and (+)-kavain, and the synthetic racemate (+/-)-kavain, were tested concerning their action on in vitro uptake of monoamines in synaptosomes prepared from the cerebral cortex and hippocampus of rats. (+/-)-Kavain and (+)-kavain were found to potently inhibit the uptake of [3H]-noradrenaline. Uptake of [3H]-noradrenaline was inhibited in the following order of potency: (+/-)-kavain = (+)-kavain > (+)-methysticine, whereas none of the kava pyrones efficiently blocked the uptake of [3H]-serotonin. The results indicate a pyrone-specific non-stereo-selective inhibition of the [3H]-noradrenaline uptake which might be responsible for or, at least, contribute to the psychotropic properties of kava pyrones.

Citations

Sep 25, 2002·Life Sciences·Anna Rita BiliaFranco F Vincieri
Jul 21, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jerome Sarris, David J Kavanagh
Sep 13, 2002·The Australian and New Zealand Journal of Psychiatry·Sheree CairneyAlan R Clough
Jul 28, 2004·Journal of Herbal Pharmacotherapy·Ethan BaschEdzard Ernst
Jul 14, 2005·Expert Opinion on Drug Safety·Catherine UlbrichtStephen Bent
Jan 20, 2009·The American Journal of Drug and Alcohol Abuse·Lin LuThomas R Kosten
Sep 13, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·J SarrisI Schweitzer
Jul 2, 2004·Organic Letters·Thomas E SmithSophie Van Alphen
Nov 16, 2010·The Australian and New Zealand Journal of Psychiatry·Jerome SarrisIsaac Schweitzer
Apr 28, 2004·Anesthesiology Clinics of North America·Alan D KayeRaj Sabar
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Elena MeseguerJusto García De Yébenes
May 29, 2004·Integrative Cancer Therapies·Keith I BlockMark N Mead
Jul 20, 2002·International Clinical Psychopharmacology·K M Connor, J R T Davidson
Jul 11, 2007·Current Opinion in Anaesthesiology·Alan D KayeRoland Hofbauer
Oct 18, 2002·CNS Drugs·Yadhu N Singh, Nirbhay N Singh
Apr 6, 2019·Current Pharmaceutical Design·Zohre FathinezhadMahmoud Rafieian-Kopaei
Oct 8, 1999·Psychosomatic Medicine·A Fugh-Berman, J M Cott
Jul 16, 2019·Journal of Forensic Sciences·Jonna BerryJustin Grodnitzky
May 3, 2013·Journal of Clinical Psychopharmacology·Jerome SarrisIsaac Schweitzer
Feb 7, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Fabrizio SchifanoJohn M Corkery
Dec 10, 2019·The Australian and New Zealand Journal of Psychiatry·Jerome SarrisCon Stough
Aug 31, 2004·CNS Spectrums·K M ConnorL E Churchill
Feb 7, 2016·Fundamental & Clinical Pharmacology·James Oluwagbamigbe FajemiroyeElson Alves Costa
Feb 6, 2021·Neurochemical Research·Lucas Dos Reis IzolanMirna Bainy Leal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.