PMID: 6407043Jan 1, 1983Paper

3H-Rauwolscine binding in platelets from depressed patients and healthy volunteers

Psychopharmacology
C PimouleS Z Langer

Abstract

3H-Rauwolscine binds specifically and with high affinity to alpha 2-adrenoceptors in human platelets. In a study comparing the binding of 3H-rauwolscine in platelets obtained from 26 control volunteers with 19 hospitalised, untreated, severely depressed patients, the mean maximal binding (Bmax) and mean dissociation constant (Kd) of 3H-rauwolscine binding were found to be identical in both groups. After 7-12 days, treatment with different tricyclic antidepressant drugs there was a significant improvement in the depressive symptoms but no change in the 3H-rauwolscine binding. After an average of 23 days treatment with tricyclic antidepressants, and when the Hamilton Depression Rating Scores had returned to normal, the Kd and Bmax of 3H-rauwolscine binding were still unchanged.

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Citations

Jan 1, 1990·Synapse·E H Cook
Nov 11, 1983·European Journal of Pharmacology·C PimouleS Z Langer
Jan 1, 1987·Journal of Psychiatric Research·A E TheodorouR W Horton
Jan 1, 1992·Molecular Aspects of Medicine·J M Elliott
Aug 1, 1986·Psychiatry Research·M E CarstensJ J Taljaard
Sep 1, 1987·Psychiatry Research·T R NormanI M McIntyre
Nov 1, 1989·Psychiatry Research·A Roy, M S Kafka
Sep 1, 1992·Psychiatry Research·F KaregeR Tissot
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·S E AuffarthE S Werstiuk
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·J E Piletz, A Halaris
Nov 1, 1986·Psychological Medicine·L BraddockK Stump
Jan 1, 1990·Pharmacology & Toxicology·G N PandeyJ M Davis
Jul 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·S J CooperD J King
Mar 1, 1986·Journal of Affective Disorders·M S KafkaE S Gershon
Nov 1, 1989·Journal of Affective Disorders·C L KatonaE S Paykel
Jan 1, 1988·Psychiatry Research·P D KanofK L Davis
May 13, 1986·European Journal of Pharmacology·J A Garcia-Sevilla, M J Fuster

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