PMID: 9526033Apr 4, 1998Paper

3H]MK-801 binding and the mRNA for the NMDAR1 subunit of the NMDA receptor are differentially distributed in human and rat forebrain

Brain Research. Molecular Brain Research
P MeoniN G Bowery

Abstract

The distributions of [3H]MK-801 binding and the NMDA NR1 subunit mRNA were studied using receptor autoradiography and in-situ hybridization in rat and human brain whole-hemisphere coronal sections. Receptor protein detected by radioligand autoradiography and the mRNA for the key subunit of the receptor presented similar distributions in the forebrain, with a few areas showing an imbalance between the levels of mRNA and receptor protein. Human frontal cortex showed a relative abundance of NMDAR1 mRNA as compared to [3H]MK-801 binding. The same area in rat brain did not show any difference in the two distributions. In comparison, the rat claustrum presented a relative excess of NMDAR1 mRNA which was not detected in human sections. Human caudate nucleus exhibited relatively high levels of [3H]MK-801 binding that were unmatched in rat caudate. The hippocampi of either species presented similar levels of [3H]MK-801 binding and NMDAR1 mRNA, but when the two signals were measured in specific subfields of the hippocampal formation, the differential distribution of the two signals reflected the anatomy of hippocampal connections assuming a preferential dendritic distribution for MK-801 binding. Interestingly, rat and human hippocampi al...Continue Reading

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Citations

Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frédéric CalonThérèse Di Paolo
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nadejda V Latysheva, Kirill S Rayevsky
May 28, 2003·Nuclear Medicine and Biology·Kjell ErlandssonLyn S Pilowsky
Mar 7, 2002·Neuroscience Letters·Maria ErikssonErik Sundström
Sep 11, 2003·The Journal of Comparative Neurology·Salvador GuiradoJosé Carlos Dávila
Nov 13, 2007·Brain Research·Anna NilssonErik Sundström
Dec 1, 2015·Frontiers in Psychiatry·Maria Cristina Patru, David H Reser
Nov 2, 2012·Journal of Neuroscience Research·E D GaierR E Mains
Aug 26, 2016·The Journal of Comparative Neurology·Minela HadzicPetra Wahle

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