PMID: 8584041Sep 1, 1995Paper

3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea pig brain: an autoradiographic study

Naunyn-Schmiedeberg's Archives of Pharmacology
C Waeber, M A Moskowitz

Abstract

We have used in vitro autoradiography to visualize [3H]sumatriptan binding sites in sections of guinea-pig and rat brain. In saturation studies, this ligand recognized a single saturable population of high affinity binding sites in all regions examined (pKD = 8.3-9.3). While 5-HT and the sumatriptan derivative CP-122,288 (5-methyl-aminosulfonylmethyl-3-(N-methylpyrrolidin-2R-yl-me thyl)- 1 H-indole) competed for [3H]sumatriptan binding sites with a high affinity and monophasic profile, displacement experiments with 5-carboxamidotryptamine revealed the existence of 2 classes of binding sites. The high affinity component (pKD = 9.2-9.9) probably corresponded to 5-HT1B (rat) or 5-HT1D (guinea-pig) receptors. The intermediate affinity (pKD = 5.7-7.3) of the other component, taken together with their high affinity for [3H]sumatriptan, was similar to that of the cloned 5-HT1F receptor. The regional distribution of the 5-HT1B/1D [3H]sumatriptan binding sites was in agreement with previously published studies (striatonigral system, hypothalamus, central gray, superficial layer of the superior colliculus) and corresponded to the pattern of serotonin-5-O-carboxymethyl-glycyl [125I]tyrosinamide labeling in consecutive sections. [3H]sumatr...Continue Reading

Citations

May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·David B WainscottDavid L Nelson
May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Virginia L LucaitesDavid L Nelson
Mar 20, 2012·Journal of Neural Transmission·J TajtiL Vécsei
Sep 14, 2004·Current Pain and Headache Reports·Peter J Goadsby
May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lars NeebUwe Reuter
Feb 9, 2002·European Journal of Pharmacology·Pankaj BhallaPramod R Saxena
May 4, 1999·European Journal of Pharmacology·D D MitsikostasC Waeber
Sep 25, 1999·European Journal of Pharmacology·U ZippelH Davidowa
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Jun 28, 2000·Progress in Neurobiology·P J Goadsby
May 30, 2002·Progress in Neurobiology·Mark J Millan
Dec 26, 2001·Brain Research Bulletin·C RobertsD N Middlemiss
Oct 19, 2010·Psychopharmacology·Sylvia Navailles, Philippe De Deurwaerdère
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Aug 21, 2013·Expert Review of Neurotherapeutics·Simon Akerman, Marcela Romero-Reyes
Sep 26, 2014·Expert Opinion on Drug Metabolism & Toxicology·János TajtiLászló Vécsei
Dec 5, 2002·Current Medical Research and Opinion·N M Ramadan
May 27, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sayamwong E HammackDonald G Rainnie
Jun 3, 2011·Headache·Saurabh GuptaB Lee Peterlin
Dec 24, 2009·Journal of Neuroscience Research·Shu-Jing ZhangLei Chen
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
Jul 3, 2007·Neurochemistry International·Gino GiannacciniAntonio Lucacchini
Jul 14, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fernando H F AlvesLeonardo B M Resstel
Sep 27, 2003·Cephalalgia : an International Journal of Headache·N M RamadanK W Johnson
Aug 1, 1996·Cephalalgia : an International Journal of Headache·J PascualA Pazos
May 1, 1997·Cephalalgia : an International Journal of Headache·P J Goadsby, Y E Knight

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.