PMID: 11910886Mar 26, 2002Paper

3rd generation progestagen and thromboembolic disease. How do we decode the information?

Gynécologie, obstétrique & fertilité
C QuereuxP Madelenat

Abstract

In 1995-1996, four studies published in different medical papers showed an increased risk of veinous thromboembolism among women using third-generation contraceptives compared with those using second-generation pills. These papers had an important mediatic impact. Nevertheless, rereading of the scientific information showed important bias in these studies (methodology, prescription, diagnosis). More recently, two studies published in the British Medical Journal analysing the venous thromboembolism (VTE) relative risk with the third generation contraceptives and using the same database (General Practitioner Research Database) found contradictory results, introducing some confusion. The use of a third-generation progestagen does seem to have led to an unexpected and yet unexplained return of a higher risk of venous thromboembolism but the risk has certainly been overestimated in the first studies.

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