3'UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis

Neuroscience Letters
Zsolt IllesBela Melegh

Abstract

The interleukin (IL) -23/IL-17 cytokine axis has been suggested to play an important role in the development of several autoimmune diseases including multiple sclerosis. Here, we compared the prevalence of C2370A single nucleotide polymorphism (SNP) in the 3' untranslated region (3'UTR) of the IL-23 receptor (IL23R) between 223 patients with relapsing-remitting multiple sclerosis (RRMS) and 200 healthy controls. The A2370A genotype was significantly over-represented among patients with RRMS (10.8%) and RRMS exhibiting oligoclonal bands in the cerebrospinal fluid (12.9%) when compared to healthy subjects (5.50%). Multiple regression analysis revealed that presence of AA genotype provides a two-fold risk for the development of multiple sclerosis (OR=2.072, 95% CI: 0.988-4.347, p<0.05). These data indicate that IL23R represents a novel shared susceptibility gene as its association with inflammatory bowel disease (IBD) has recently been verified.

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Citations

Sep 29, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govardhana Rao YannamLarisa Y Poluektova
Jul 25, 2008·Genes and Immunity·V E GarciaS J Schrodi
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Feb 4, 2014·Clinics and Research in Hepatology and Gastroenterology·Nasser Ebrahimi DaryaniNima Rezaei
May 23, 2015·The International Journal of Neuroscience·Jian HuangFeng Li
May 1, 2011·Expert Opinion on Medical Diagnostics·John W Rose, Noel G Carlson
May 9, 2012·Immunobiology·Dragana Popovic-KuzmanovicVladimir Trajkovic
Jan 20, 2010·Cancer Genetics and Cytogenetics·Zhu ZhangMing-Rong Xi
Mar 27, 2009·The Journal of Investigative Dermatology·Antonella Di CesareFrank O Nestle
Apr 11, 2008·Immunity·Mandy J McGeachy, Daniel J Cua
Feb 5, 2014·Expert Review of Clinical Immunology·Aristeidis H Katsanos, Konstantinos H Katsanos
Jul 10, 2018·Immunological Investigations·Maheshkumar PoomarimuthuJayalakshmi Mariakuttikan
Dec 17, 2008·Annals of the New York Academy of Sciences·Gustavo J MartinezChen Dong

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