4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with simple olefins: facile approaches to tetrahydropyridazines

Organic Letters
Xingren ZhongSanzhong Luo

Abstract

A catalyst-free [4 + 2] annulation process between in situ generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield).

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Citations

Mar 24, 2016·Chemical Communications : Chem Comm·Guojiao WuJianbo Wang
Dec 10, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Wei WangHaifeng Du
Aug 1, 2015·Chemistry : a European Journal·Chenghao ZhuJiangtao Sun

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