PMID: 8951452Dec 1, 1996Paper

4-Aminopyridine effects on summating potentials in the guinea pig

Hearing Research
M G van EmstG F Smoorenburg

Abstract

DC receptor potentials measured in hair cells, and the associated extracellular DC potential known as the summating potential (SP), originate with nonlinear elements in the mechanoelectric transduction chain. Nonlinear electric conductance has been demonstrated in the basolateral membrane of the hair cell, and is commonly attributed to the presence of voltage- and time-dependent K+ conductances in this part of the hair cell membrane. To study a possible contribution of these K+ channels to the SP we perfused the perilymphatic spaces of the guinea pig cochlea with the K+ channel blocker 4-aminopyridine (4-AP). Since 4-AP might also affect the afferent fibers and, thus, interfere with SP measurement, we added tetrodotoxin (TTX) to the perfusion solutions to block the neuronal discharges. Sound-evoked (2-12 kHz) intracochlear potentials were recorded from the basal turn of both scala vestibuli and scala tympani. The results showed a frequency- and level-dependent effect of 4-AP on the magnitude of the SP. At low and moderate levels of 8 and 12 kHz stimuli 4-AP mostly reduced the SP amplitude, while at high levels of these stimuli and at all levels of 2 and 4 kHz stimuli 4-AP enlarged the SP amplitude. These effects were reversible...Continue Reading

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Citations

Dec 18, 2004·The Journal of the Acoustical Society of America·Chul-Hee ChoiDavid Lerner
Dec 28, 1999·Brain : a Journal of Neurology·K J SmithG R John
Nov 29, 2017·Scientific Reports·Abdelbaset SuleimanZahra Moussavi
Nov 24, 1999·The American Journal of Physiology·T van Den AbbeeleP T Huy

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