4-D Computational Modeling of Cardiac Outflow Tract Hemodynamics over Looping Developmental Stages in Chicken Embryos.

Journal of Cardiovascular Development and Disease
Katherine CourchaineSandra Rugonyi

Abstract

Cardiogenesis is interdependent with blood flow within the embryonic system. Recently, a number of studies have begun to elucidate the effects of hemodynamic forces acting upon and within cells as the cardiovascular system begins to develop. Changes in flow are picked up by mechanosensors in endocardial cells exposed to wall shear stress (the tangential force exerted by blood flow) and by myocardial and mesenchymal cells exposed to cyclic strain (deformation). Mechanosensors stimulate a variety of mechanotransduction pathways which elicit functional cellular responses in order to coordinate the structural development of the heart and cardiovascular system. The looping stages of heart development are critical to normal cardiac morphogenesis and have previously been shown to be extremely sensitive to experimental perturbations in flow, with transient exposure to altered flow dynamics causing severe late stage cardiac defects in animal models. This paper seeks to expand on past research and to begin establishing a detailed baseline for normal hemodynamic conditions in the chick outflow tract during these critical looping stages. Specifically, we will use 4-D (3-D over time) optical coherence tomography to create in vivo geometries...Continue Reading

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May 18, 2018·Progress in Biophysics and Molecular Biology·Katherine CourchaineSandra Rugonyi

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Citations

Apr 29, 2020·Biomedical Optics Express·Shang WangKirill V Larin
Sep 30, 2020·Journal of Cardiovascular Development and Disease·Deborah J HendersonBill Chaudhry
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Huseyin Enes Salman, Huseyin Cagatay Yalcin

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