4-HNE expression in diabetic rat kidneys and the protective effects of probucol

Journal of Endocrinological Investigation
G LiuY Wang

Abstract

To investigate 4-HNE expression in diabetic rat kidneys and the protective effect of probucol. Diabetic rat models were established. Diabetic rats with successful modeling were randomly divided into the diabetic group (group D) and probucol treated group (group P). Normal rats were put into the control group (group C). Rats in group P were treated with probucol (110 mg/kg day), and rats in groups D and C were given equal volume of water instead. Serum creatinine (SCr), urea nitrogen (BUN), triglyceride (TG), total cholesterol (TC), and 24-h urinary protein were measured at the 4th, 8th, and 12th weeks. Periodic acid-schiff (PAS) staining and hematoxylin-eosin (HE) staining were used to evaluate the renal pathological changes. The immunohistochemistry and Western-blot were used to detect 4-HNE expression in renal tissue. The SCr, BUN, TG, TC, and 24-h urinary protein in group D increased in the 4th, 8th, and 12th weeks and were higher than those in group C (P < 0.05). The SCr, BUN, TG, TC, and 24-h urinary protein in group P decreased compared to group D (P < 0.05). Pathological kidney changes in group D were more serious than those in group P. The level of 4-HNE expression in group D significantly increased at the 4th, 8th, and...Continue Reading

References

Nov 20, 2002·Chemical Research in Toxicology·Jonathan A Doorn, Dennis R Petersen
Apr 20, 2004·Japanese Heart Journal·Takayuki YokoyamaHiroyuki Daida
Jun 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengMoon-Shong Tang
Apr 1, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hongwei YaoIrfan Rahman
Jun 23, 2010·Biochemistry·Pankaj ChaudharyYogesh C Awasthi
Apr 1, 2011·Chemical Research in Toxicology·Kristofer S FritzDennis R Petersen
Aug 18, 2012·Biochemical and Biophysical Research Communications·Wan-Chi LeeShin-Hai Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Feng XiaoHui Wang
Clinical and Investigative Medicine. Médecine Clinique Et Experimentale
Yu LiWeide Zhong
© 2021 Meta ULC. All rights reserved