4-Hydroxy cinnamic acid as mushroom preservation: Anti-tyrosinase activity kinetics and application.

International Journal of Biological Macromolecules
Yong-Hua HuQin Wang

Abstract

Tyrosinase is a key enzyme in post-harvest browning of fruit and vegetable. To control and inhibit its activity is the most effective method for delaying the browning and extend the shelf life. In this paper, the inhibitory kinetics of 4-hydroxy cinnamic acid on mushroom tyrosinase was investigated using the kinetics method of substrate reaction. The results showed that the inhibition of tyrosinase by 4-hydroxy cinnamic acid was a slow, reversible reaction with fractional remaining activity. The microscopic rate constants were determined for the reaction on 4-hydroxy cinnamic acid with tyrosinase. Furthermore, the molecular docking was used to simulate 4-hydroxy cinnamic acid dock with tyrosinase. The results showed that 4-hydroxy cinnamic acid interacted with the enzyme active site mainly through the hydroxy competed with the substrate hydroxy group. The cytotoxicity study of 4-hydroxy cinnamic acid indicated that it had no effects on the proliferation of normal liver cells. Moreover, the results of effects of 4-hydroxy cinnamic acid on the preservation of mushroom showed that it could delay the mushroom browning. These results provide a comprehensive underlying the inhibitory mechanisms of 4-hydroxy cinnamic acid and its dela...Continue Reading

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Citations

Oct 12, 2016·Scientific Reports·Batel DeriAyelet Fishman
Sep 7, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrei MocanAdriano Mollica
Aug 29, 2019·Critical Reviews in Food Science and Nutrition·Anurag Khatkar, Krishna Kant Sharma
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Apr 27, 2021·International Journal of Environmental Health Research·Elif Ayşe Erdoğan Eliuz
Apr 8, 2017·Journal of Agricultural and Food Chemistry·Antonio Garcia-JimenezFrancisco García-Cánovas

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