4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs

Biochemical and Biophysical Research Communications
Fumiyuki NakagawaHiroshi Maegawa

Abstract

It has recently been reported that expression of heme oxygenase-1 (HO-1) plays a protective role against many diseases. Furthermore, n-3 polyunsaturated fatty acids (PUFAs) were shown to induce HO-1 expression in several cells in vitro, and in a few cases also in vivo. However, very few reports have demonstrated that n-3 PUFAs induce HO-1 in vivo. In this study, we examined the effect of fish-oil dietary supplementation on the distribution of fatty acids and their peroxidative metabolites and on the expression of HO-1 in multiple tissues (liver, kidney, heart, lung, spleen, intestine, skeletal muscle, white adipose, brown adipose, brain, aorta, and plasma) of C57BL/6 mice. Mice were divided into 4 groups, and fed a control, safflower-oil, and fish-oil diet for 3 weeks. One group was fed a fish-oil diet for just 1 week. The concentration of fatty acids, 4-hydroxy hexenal (4-HHE), and 4-hydroxy nonenal (4-HNE), and the expression of HO-1 mRNA were measured in the same tissues. We found that the concentration of 4-HHE (a product of n-3 PUFAs peroxidation) and expression of HO-1 mRNA were significantly increased after fish-oil treatment in most tissues. In addition, these increases were paralleled by an increase in the level of doc...Continue Reading

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Citations

Oct 18, 2015·Toxicology and Applied Pharmacology·Sharad S SinghalSanjay Awasthi
Dec 30, 2014·Molecular Nutrition & Food Research·Baukje de Roos, Garry G Duthie
Dec 21, 2016·Toxicology Mechanisms and Methods·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Jul 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Wendy T K IpLea M D Delbridge
May 26, 2018·Systems Biology in Reproductive Medicine·Xuechun HuBing Yao
Sep 27, 2020·Progress in Lipid Research·Paolo AbresciaPaolo Bergamo

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