4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

Nature Neuroscience
Nikolaos KaralisCyril Herry

Abstract

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.

References

Jun 1, 1992·Journal of Neurophysiology·M P YoungS Yamane
Feb 4, 1999·Biophysical Journal·P P Mitra, B Pesaran
Mar 22, 2001·Nature Reviews. Neuroscience·J C Magee
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·D M ViannaM L Brandão
Jan 22, 2003·Neuroscience·G BuzsákiA Morozov
Aug 9, 2003·Science·Thomas SeidenbecherHans-Christian Pape
Jul 27, 2004·Nature Neuroscience·Rainer W FriedrichGilles Laurent
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Guido NolteMark Hallett
Apr 12, 2005·Neuron·Athanassios G SiapasMatthew A Wilson
Oct 1, 2005·The Journal of Comparative Neurology·Paul L A GabbottSarah J Busby
Nov 18, 2008·Journal of Neuroscience Methods·Hendrik W Steenland, Min Zhuo
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hari H SubramanianGert Holstege
Oct 11, 2011·Neuron·Shigeyoshi Fujisawa, György Buzsáki
Oct 25, 2011·Cell·Inbal GoshenKarl Deisseroth
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hendrik W SteenlandMin Zhuo
Nov 5, 2013·Nature Neuroscience·Sachin P Vaidya, Daniel Johnston
Nov 10, 2013·Journal of Neuroscience Methods·Lionel Barnett, Anil K Seth
Nov 19, 2013·Nature Neuroscience·Ekaterina LikhtikJoshua A Gordon
Dec 10, 2013·Neuron·Eran StarkGyörgy Buzsáki

❮ Previous
Next ❯

Citations

Jul 15, 2016·Nature·Cyril DejeanCyril Herry
Oct 25, 2016·PloS One·Thomas F GiustinoStephen Maren
Dec 7, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cyril DejeanCatherine Le Moine
Oct 22, 2016·Scientific Reports·Matthieu O PasquetGuillaume P Dugué
Mar 30, 2017·Scientific Reports·Jonatan BiskampJonas-Frederic Sauer
Mar 23, 2017·PloS One·Sorinel A Oprisan, Dave I Austin
Oct 3, 2017·Nature Neuroscience·Patrick DavisLeon G Reijmers
Nov 1, 2018·Psychopharmacology·Nicolas Singewald, Andrew Holmes
Mar 22, 2019·Stress : the International Journal on the Biology of Stress·Yuchen WangLing Qin
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Elise Holter ThompsonMarianne Fyhn
Aug 7, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Aaron S Heller
Apr 26, 2017·Frontiers in Neural Circuits·Christine A DennySteve Ramirez
Sep 13, 2017·PLoS Biology·Omar MamadMarian Tsanov
Dec 10, 2017·Brain Structure & Function·Bernat KocsisAlexis Roy
Sep 26, 2019·Nature Neuroscience·Ekaterina Likhtik, Joshua P Johansen
Jul 6, 2017·Current Protocols in Neuroscience·Alexander Z HarrisEkaterina Likhtik
Dec 1, 2017·Brain : a Journal of Neurology·Ryan KelleyNandakumar S Narayanan
Mar 7, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Carlos Del Rio-Bermudez, Mark S Blumberg
May 8, 2018·Frontiers in Cellular Neuroscience·Áron KőszeghyThomas Klausberger
Aug 23, 2018·Frontiers in Neural Circuits·Daniel AvesarAllan T Gulledge
Sep 22, 2018·Psychopharmacology·Jelena RadulovicCan Gao
Nov 13, 2018·Psychopharmacology·Gürsel Çalışkan, Oliver Stork
Jun 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Rongzhen YanQiang Zhou
Mar 1, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas Roseberry, Anatol Kreitzer
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Weiwei ZhongAndreas Draguhn
Apr 25, 2018·Scientific Reports·Adriano B L TortAndreas Draguhn
May 5, 2018·Biomedicines·Carlos TrenadoDiane Ruge
Nov 23, 2018·Scientific Reports·Ryan A SelleckJ Amiel Rosenkranz
May 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Donald PfaffWulf Haubensak
Aug 29, 2019·Frontiers in Cellular Neuroscience·Jordi DuranJoan J Guinovart
Mar 21, 2020·Nature Communications·Yuan HanJelena Radulovic
May 25, 2016·Molecular Psychiatry·F H Do MonteM A Penzo

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Software Mentioned

Power3
MVGC
Matlab

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.