4-methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-DMAR, 4,4'-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity

Human Psychopharmacology
James GlanvilleD M Wood

Abstract

4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-dimethylaminorex (4,4'-DMAR)) is a derivative of the controlled substances aminorex and 4-methylaminorex marketed as a potential novel psychoactive substance. This paper brings together the published scientific and 'grey' literature to understand 4,4'-DMAR as a novel psychoactive substance. Searches of the published scientific and 'grey' literature, using the keywords '4-methyl-euphoria', '4-methyl-U4Euh', '4-M-4-MAR', '4,4-dimethylaminorex', '4,4'-DMAR', 'para-methyl-4-aminorex' and 'Serotoni', were undertaken to identify information on the availability, prevalence of use and desired/unwanted effects of 4,4'-DMAR. No studies have reported the prevalence of use of 4,4'-DMAR. Internet snapshot studies in April and May 2014 showed availability of 4,4'-DMAR from one and two Internet suppliers respectively. Price decreased with increasing purchase amounts from €12/g for a 1-g purchase to €2.20/g for a 100-g purchase in April 2014. Internet discussion fora suggest that the desired and unwanted effects of 4,4'-DMAR are similar to those seen with other sympathomimetic drugs such as 3,4-methylenedioxy-methamphetamine and mephedrone, although the duration of unwanted effects an...Continue Reading

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Citations

Feb 19, 2016·Drug Testing and Analysis·Tibor M BruntMireia Ventura Vilamala
Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
Aug 30, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Hisham NizarDavid M Wood
Jun 29, 2017·Human Psychopharmacology·Barbara LoiFabrizio Schifano
Nov 14, 2019·The Indian Journal of Medical Research·Deepika DhingraJagat Ram
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Oct 3, 2018·ACS Chemical Neuroscience·Julian MaierHarald H Sitte

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